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Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance.

Kirwan, DE; Ugarte-Gil, C; Gilman, RH; Caviedes, L; Rizvi, H; Ticona, E; Chavez, G; Cabrera, JL; Matos, ED; Evans, CA; et al. Kirwan, DE; Ugarte-Gil, C; Gilman, RH; Caviedes, L; Rizvi, H; Ticona, E; Chavez, G; Cabrera, JL; Matos, ED; Evans, CA; Moore, DAJ; Friedland, JS; Lymph Node TB Working Group, Peru (2016) Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance. J Clin Microbiol, 54 (1). pp. 185-189. ISSN 1098-660X https://doi.org/10.1128/JCM.02227-15
SGUL Authors: Friedland, Jonathan Samuel

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Abstract

In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

Item Type: Article
Additional Information: Copyright © 2015 Kirwan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/).
Keywords: Adolescent, Adult, Aged, Aged, 80 and over, Bacteriological Techniques, Female, Humans, Male, Microscopy, Middle Aged, Sensitivity and Specificity, Time Factors, Tuberculosis, Lymph Node, Tuberculosis, Multidrug-Resistant, Young Adult, Lymph Node TB Working Group, Peru, Humans, Tuberculosis, Lymph Node, Tuberculosis, Multidrug-Resistant, Microscopy, Bacteriological Techniques, Sensitivity and Specificity, Time Factors, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Young Adult, 06 Biological Sciences, 07 Agricultural And Veterinary Sciences, 11 Medical And Health Sciences, Microbiology
Journal or Publication Title: J Clin Microbiol
ISSN: 1098-660X
Language: eng
Publisher License: Creative Commons: Attribution 3.0
Projects:
Project IDFunderFunder ID
MR/K007467/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
PubMed ID: 26511739
Web of Science ID: WOS:000367537600033
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110639
Publisher's version: https://doi.org/10.1128/JCM.02227-15

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