Rao, VB; Pelly, TF; Gilman, RH; Cabrera, L; Delgado, J; Soto, G; Friedland, JS; Escombe, AR; Black, RE; Evans, CA
(2007)
Zinc cream and reliability of tuberculosis skin testing.
Emerg Infect Dis, 13 (7).
pp. 1101-1104.
ISSN 1080-6040
https://doi.org/10.3201/eid1307.070227
SGUL Authors: Friedland, Jonathan Samuel
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Abstract
In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune responses enough to improve diagnosis.
| Item Type: |
Article
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| Keywords: |
Administration, Topical, Adult, Diagnosis, Differential, Double-Blind Method, False Negative Reactions, Female, Humans, Male, Nutritional Status, Peru, Reproducibility of Results, Risk Factors, Sensitivity and Specificity, Skin, Social Class, Socioeconomic Factors, Trace Elements, Tuberculin Test, Tuberculosis, Zinc, Skin, Humans, Tuberculosis, Zinc, Trace Elements, Diagnosis, Differential, False Negative Reactions, Tuberculin Test, Administration, Topical, Risk Factors, Sensitivity and Specificity, Double-Blind Method, Reproducibility of Results, Nutritional Status, Social Class, Socioeconomic Factors, Adult, Peru, Female, Male, Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, MALNUTRITION, 1108 Medical Microbiology, 1117 Public Health And Health Services, 1103 Clinical Sciences, Microbiology |
| Journal or Publication Title: |
Emerg Infect Dis |
| ISSN: |
1080-6040 |
| Language: |
eng |
| Dates: |
| Date | Event |
|---|
| July 2007 | Published |
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| Publisher License: |
Publisher's own licence |
| Projects: |
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| PubMed ID: |
18214192 |
| Web of Science ID: |
WOS:000247758200027 |
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Go to PubMed abstract |
| URI: |
https://openaccess.sgul.ac.uk/id/eprint/110605 |
| Publisher's version: |
https://doi.org/10.3201/eid1307.070227 |
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