Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB).

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Saenger, AK; Jaffe, AS; Body, R; Collinson, PO; Kavsak, PA; Lam, CSP; Lefèvre, G; Omland, T; Ordóñez-Llanos, J; Pulkki, K; et al. Saenger, AK; Jaffe, AS; Body, R; Collinson, PO; Kavsak, PA; Lam, CSP; Lefèvre, G; Omland, T; Ordóñez-Llanos, J; Pulkki, K; Apple, FS (2019) Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB). Clin Chem Lab Med, 57 (5). pp. 633-640. ISSN 1437-4331 https://doi.org/10.1515/cclm-2018-0905
SGUL Authors: Collinson, Paul

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Abstract

Two interferences recently brought to the forefront as patient safety issues include hemolysis (hemoglobin) and biotin (vitamin B7). The International Federation for Clinical Chemistry Committee on Cardiac Biomarkers (IFCC-CB) obtained input from a majority of cTn and NP assay manufacturers to collate information related to high-sensitivity (hs)-cTnI, hs-cTnT, contemporary, and POC cTn assays, and NP assays interferences due to hemolysis and biotin. The information contained in these tables was designed as educational tools to aid laboratory professionals and clinicians in troubleshooting cardiac biomarker analytical results that are discordant with the clinical situation.

Item Type:

Article

Additional Information:

Keywords:

biotin, hemolysis, interferences, natriuretic peptide, troponin, 1103 Clinical Sciences, 1702 Cognitive Science, General Clinical Medicine

SGUL Research Institute / Research Centre:

Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)

Journal or Publication Title:

Clin Chem Lab Med

ISSN:

1437-4331

Language: