Molloy, SF;
Bradley, J;
Karunaharan, N;
Mputu, M;
Stone, N;
Phulusa, J;
Chawinga, C;
Gaskell, K;
Segula, D;
Ming, D;
et al.
Molloy, SF; Bradley, J; Karunaharan, N; Mputu, M; Stone, N; Phulusa, J; Chawinga, C; Gaskell, K; Segula, D; Ming, D; Peirse, M; Chanda, D; Lakhi, S; Loyse, A; Kanyama, C; Heyderman, RS; Harrison, TS
(2018)
Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis.
AIDS, 32 (15).
pp. 2259-2261.
ISSN 1473-5571
https://doi.org/10.1097/QAD.0000000000001961
SGUL Authors: Harrison, Thomas Stephen Molloy, Sile Loyse, Angela
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Abstract
We assessed the effect of fluconazole 1200 mg/day on the QT interval in cryptococcal meningitis patients. Mean corrected QT (QTc) change from baseline to day 7 was 10.1 ms (IQR: -28 to 46 ms) in the fluconazole treatment group and -12.6 ms (IQR: -39 to 13.5 ms) in those not taking fluconazole (P = 0.04). No significant increase in QTc measurements over 500 ms was observed with fluconazole. Nevertheless, it remains important to correct any electrolyte imbalance and avoid concomitant drugs that may increase QTc.
| Item Type: | Article | |||||||||
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| Additional Information: | Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||
| Keywords: | 06 Biological Sciences, 11 Medical And Health Sciences, 17 Psychology And Cognitive Sciences, Virology | |||||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | |||||||||
| Journal or Publication Title: | AIDS | |||||||||
| ISSN: | 1473-5571 | |||||||||
| Language: | eng | |||||||||
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| Publisher License: | Publisher's own licence | |||||||||
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| PubMed ID: | 30102652 | |||||||||
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/110079 | |||||||||
| Publisher's version: | https://doi.org/10.1097/QAD.0000000000001961 |
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