Chen, J-C; Macerollo, A; Sadnicka, A; Lu, M-K; Tsai, C-H; Korlipara, P; Bhatia, K; Rothwell, JC; Edwards, MJ
(2018)
Cervical dystonia: Normal auditory mismatch negativity and abnormal somatosensory mismatch negativity.
Clin Neurophysiol, 129 (9).
pp. 1947-1954.
ISSN 1872-8952
https://doi.org/10.1016/j.clinph.2018.05.028
SGUL Authors: Sadnicka, Anna
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Abstract
OBJECTIVE: Previous electrophysiological and psychophysical tests have suggested that somatosensory integration is abnormal in dystonia. Here, we hypothesised that this abnormality could relate to a more general deficit in pre-attentive error/deviant detection in patients with dystonia. We therefore tested patients with dystonia and healthy subjects using a mismatch negativity paradigm (MMN), where evoked potentials generated in response to a standard repeated stimulus are subtracted from the responses to a rare "odd ball" stimulus. METHODS: We assessed MMN for somatosensory and auditory stimuli in patients with cervical dystonia and healthy age matched controls. RESULTS: We found a significant group ∗ oddball type interaction effect (F (1, 34) = 4.5, p = 0.04, ρI = 0.63). A follow up independent t-test for sMMN data, showed a smaller sMMN amplitude in dystonic patients compared to controls (mean difference control-dystonia: -1.0 µV ± 0.3, p < 0.00, t = -3.1). However the amplitude of aMMN did not differ between groups (mean difference control-dystonia: -0.2 µV ± 0.2, p = 0.24, t = -1.2). We found a positive correlation between somatosensory MMN and somatosensory temporal discrimination threshold. CONCLUSION: These results suggest that pre-attentive error/deviant detection, specifically in the somatosensory domain, is abnormal in dystonia. This could underlie some previously reported electrophysiological and psychophysical abnormalities of somatosensory integration in dystonia. SIGNIFICANCE: One could hypothesize a deficit in pre-conscious orientation towards potentially salient signals might lead to a more conservative threshold for decision-making in dystonia.
Item Type: | Article | ||||||||
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Additional Information: | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | ||||||||
Keywords: | Dystonia, Mismatch negativity (MMN), Somatosensory integration, Mismatch negativity (MMN), Dystonia, Somatosensory integration, Dystonia, Mismatch negativity (MMN), Somatosensory integration, Neurology & Neurosurgery, 11 Medical And Health Sciences, 17 Psychology And Cognitive Sciences, 09 Engineering | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) | ||||||||
Journal or Publication Title: | Clin Neurophysiol | ||||||||
ISSN: | 1872-8952 | ||||||||
Language: | eng | ||||||||
Dates: |
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Publisher License: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | ||||||||
PubMed ID: | 30015084 | ||||||||
Web of Science ID: | WOS:000440658200020 | ||||||||
Go to PubMed abstract | |||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/110077 | ||||||||
Publisher's version: | https://doi.org/10.1016/j.clinph.2018.05.028 |
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