Genetics of Severe Obesity

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Fairbrother, U; Kidd, E; Malagamuwa, T; Walley, AJ (2018) Genetics of Severe Obesity. Current Diabetes Reports, 18. p. 85. ISSN 1539-0829 https://doi.org/10.1007/s11892-018-1053-x
SGUL Authors: Walley, Andrew John

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Abstract

Purpose of Review This review aims to present current information on genes underlying severe obesity, with the main emphasis on the three genes LEP, LEPR and MC4R. Recent Findings There is a substantial amount of evidence that variants in at least ten different genes are the cause of severe monogenic obesity. The majority of these are involved in the leptin-melanocortin signalling pathway. Due to the frequency of some of the identified variants, it is clear that monogenic variants also make a significant contribution to common obesity. Summary The artificial distinction between rare monogenic obesity and common polygenic obesity is now obsolete with the identification of MC4R variants of strong effect in the general population. Keywords Obesity Leptin Melanocortin-4 receptor GWAS BMI

Item Type:

Article

Additional Information:

© The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Keywords:

Endocrinology & Metabolism

SGUL Research Institute / Research Centre:

Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)

Journal or Publication Title:

Current Diabetes Reports

ISSN:

1539-0829

Dates: