Martinez-Morales, J-R; Cavodeassi, F; Bovolenta, P
(2017)
Coordinated Morphogenetic Mechanisms Shape the Vertebrate Eye.
Front Neurosci, 11.
p. 721.
ISSN 1662-4548
https://doi.org/10.3389/fnins.2017.00721
SGUL Authors: Cavodeassi, Florencia
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Abstract
The molecular bases of vertebrate eye formation have been extensively investigated during the past 20 years. This has resulted in the definition of the backbone of the gene regulatory networks controlling the different steps of eye development and has further highlighted a substantial conservation of these networks among vertebrates. Yet, the precise morphogenetic events allowing the formation of the optic cup from a small group of cells within the anterior neural plate are still poorly understood. It is also unclear if the morphogenetic events leading to eyes of very similar shape are indeed comparable among all vertebrates or if there are any species-specific peculiarities. Improved imaging techniques have enabled to follow how the eye forms in living embryos of a few vertebrate models, whereas the development of organoid cultures has provided fascinating tools to recapitulate tissue morphogenesis of other less accessible species. Here, we will discuss what these advances have taught us about eye morphogenesis, underscoring possible similarities and differences among vertebrates. We will also discuss the contribution of cell shape changes to this process and how morphogenetic and patterning mechanisms integrate to assemble the final architecture of the eye.
Item Type: | Article | ||||||
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Additional Information: | Copyright © 2017 Martinez-Morales, Cavodeassi and Bovolenta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | ||||||
Keywords: | cell movement, cell shape, eye development, morphogenesis, patterning, retina pigment epithelim, vertebrates, 1109 Neurosciences, 1702 Cognitive Science | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > Institute of Medical & Biomedical Education (IMBE) Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE) |
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Journal or Publication Title: | Front Neurosci | ||||||
ISSN: | 1662-4548 | ||||||
Language: | eng | ||||||
Dates: |
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PubMed ID: | 29326547 | ||||||
Go to PubMed abstract | |||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/110018 | ||||||
Publisher's version: | https://doi.org/10.3389/fnins.2017.00721 |
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