Char, A; Hopkinson, NS; Hansell, DM; Nicholson, AG; Shaw, EC; Clark, SJ; Sedgwick, P; Wilson, R; Jordan, S; Loebinger, MR
(2014)
Evidence of mycobacterial disease in COPD patients with lung volume reduction surgery; the importance of histological assessment of specimens: a cohort study.
BMC Pulmonary Medicine, 14 (1).
p. 124.
ISSN 1471-2466
https://doi.org/10.1186/1471-2466-14-124
SGUL Authors: Sedgwick, Philip Martin
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Abstract
Background Patients with COPD are at risk of non-tuberculous mycobacterial infection (NTM). This study examined the histology of lung tissue from COPD patients following lung volume reduction with particular focus on evidence of mycobacterial infection. Methods Retrospective histological study of 142 consecutive lung volume reduction surgical specimens (126 separate patients) at Royal Brompton Hospital between 2000 – 2013, with prospectively collected preoperative data on exacerbation rate, lung function and body mass index. Results 92% of patients had at least one other histological diagnosis in addition to emphysema. 10% of specimens had histological evidence of mycobacterial infection, one with co-existent aspergilloma. Mycobacteria were only identified in those patients with granulomas that were necrotising. These patients had higher exacerbation rates, lower TLCO and FEV1. Conclusion A proportion of severe COPD patients will have evidence of mycobacterial infection despite lack of clinical and radiological suspicion. This may have implications for long-term management of these patients.
Item Type: | Article | ||||||||
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Additional Information: | © 2014 Char et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | ||||||||
Keywords: | Respiratory System, 1102 Cardiovascular Medicine And Haematology | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Institute of Medical & Biomedical Education (IMBE) Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE ) |
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Journal or Publication Title: | BMC Pulmonary Medicine | ||||||||
ISSN: | 1471-2466 | ||||||||
Dates: |
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Publisher License: | Creative Commons: Attribution 4.0 | ||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/109990 | ||||||||
Publisher's version: | https://doi.org/10.1186/1471-2466-14-124 |
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