Standardization of autoimmune testing - is it feasible?

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Monogioudi, E; Martos, G; Hutu, DP; Schimmel, H; Meroni, PL; Sheldon, J; Zegers, I (2018) Standardization of autoimmune testing - is it feasible? Clin Chem Lab Med, 56 (10). pp. 1734-1742. ISSN 1437-4331 https://doi.org/10.1515/cclm-2017-1077
SGUL Authors: Sheldon, Joanna

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Abstract

Correct measurement of autoantibodies is essential for the diagnosis of autoimmune diseases. However, due to the variability of autoantibody results and the heterogeneity of testing, wrong diagnosis is a reality. For this and more reasons, harmonization of testing is of the outmost importance. In this review we have summarized the factors contributing to this variability. The ways with which the working group on harmonization of autoantibody testing of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has been trying to tackle the issue with the production and correct use of certified reference materials (CRMs), is discussed. Finally the advantages and the limitations of the use of CRMs are presented.

Item Type:

Article

Additional Information:

©2018 Evanthia Monogioudi et al., published by De Gruyter, Berlin/Boston. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. CC BY-NC-ND 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0)

Keywords:

autoimmune disease, certified reference materials, harmonization, standardization, autoimmune disease, certified reference materials, harmonization, standardization, General Clinical Medicine, 1103 Clinical Sciences, 1702 Cognitive Science

SGUL Research Institute / Research Centre:

Academic Structure > Infection and Immunity Research Institute (INII)

Journal or Publication Title:

Clin Chem Lab Med

ISSN:

1437-4331

Language:

eng

Dates: