Donin, AS;
Dent, JE;
Nightingale, CM;
Sattar, N;
Owen, CG;
Rudnicka, AR;
Perkin, MR;
Stephen, AM;
Jebb, SA;
Cook, DG;
et al.
Donin, AS; Dent, JE; Nightingale, CM; Sattar, N; Owen, CG; Rudnicka, AR; Perkin, MR; Stephen, AM; Jebb, SA; Cook, DG; Whincup, PH
(2016)
Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin resistance and glycaemia in 9-10 year-old children.
Diabet Med, 33 (3).
pp. 307-315.
ISSN 1464-5491
https://doi.org/10.1111/dme.13006
SGUL Authors: Cook, Derek Gordon Nightingale, Claire Owen, Christopher Grant Rudnicka, Alicja Regina Whincup, Peter Hynes Donin, Angela Perkin, Michael Richard
Abstract
AIM: To examine whether low circulating vitamin C concentrations and low fruit and vegetable intakes were associated with insulin resistance and other Type 2 diabetes risk markers in childhood. METHODS: We conducted a cross-sectional, school-based study in 2025 UK children aged 9-10 years, predominantly of white European, South-Asian and black African origin. A 24-h dietary recall was used to assess fruit, vegetable and vitamin C intakes. Height, weight and fat mass were measured and a fasting blood sample collected to measure plasma vitamin C concentrations and Type 2 diabetes risk markers. RESULTS: In analyses adjusting for confounding variables (including socio-economic status), a one interquartile range higher plasma vitamin C concentration (30.9 μmol/l) was associated with a 9.6% (95% CI 6.5, 12.6%) lower homeostatic model assessment of insulin resistance value, 0.8% (95% CI 0.4, 1.2%) lower fasting glucose, 4.5% (95% CI 3.2, 5.9%) lower urate and 2.2% (95% CI 0.9, 3.4%) higher HDL cholesterol. HbA1c concentration was 0.6% (95% CI 0.2, 1.0%) higher. Dietary fruit, vegetable and total vitamin C intakes were not associated with any Type 2 diabetes risk markers. Lower plasma vitamin C concentrations in South-Asian and black African-Caribbean children could partly explain their higher insulin resistance. CONCLUSIONS: Lower plasma vitamin C concentrations are associated with insulin resistance and could partly explain ethnic differences in insulin resistance. Experimental studies are needed to establish whether increasing plasma vitamin C can help prevent Type 2 diabetes at an early stage.
Item Type: |
Article
|
Additional Information: |
© 2015 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: |
Ascorbic Acid, Blood Glucose, Child, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diet, Eating, Female, Fruit, Humans, Insulin Resistance, Male, Risk Factors, Socioeconomic Factors, United Kingdom, Vegetables, Endocrinology & Metabolism, 1103 Clinical Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Population Health Research Institute (INPH) |
Journal or Publication Title: |
Diabet Med |
ISSN: |
1464-5491 |
Language: |
eng |
Dates: |
Date | Event |
---|
11 February 2016 | Published | 23 November 2015 | Published Online | 24 October 2015 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
|
PubMed ID: |
26498636 |
Web of Science ID: |
WOS:000351177500159 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/109806 |
Publisher's version: |
https://doi.org/10.1111/dme.13006 |
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