Michowitz, Y;
Milman, A;
Sarquella-Brugada, G;
Andorin, A;
Champagne, J;
Postema, PG;
Casado-Arroyo, R;
Leshem, E;
Juang, JJ;
Giustetto, C;
et al.
Michowitz, Y; Milman, A; Sarquella-Brugada, G; Andorin, A; Champagne, J; Postema, PG; Casado-Arroyo, R; Leshem, E; Juang, JJ; Giustetto, C; Tfelt-Hansen, J; Wijeyeratne, YD; Veltmann, C; Corrado, D; Kim, S-H; Delise, P; Maeda, S; Gourraud, J-B; Sacher, F; Mabo, P; Takahashi, Y; Kamakura, T; Aiba, T; Conte, G; Hochstadt, A; Mizusawa, Y; Rahkovich, M; Arbelo, E; Huang, Z; Denjoy, I; Napolitano, C; Brugada, R; Calo, L; Priori, SG; Takagi, M; Behr, ER; Gaita, F; Yan, G-X; Brugada, J; Leenhardt, A; Wilde, AAM; Brugada, P; Kusano, KF; Hirao, K; Nam, G-B; Probst, V; Belhassen, B
(2018)
Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome.
Heart Rhythm, 15 (9).
pp. 1394-1401.
ISSN 1556-3871
https://doi.org/10.1016/j.hrthm.2018.04.007
SGUL Authors: Behr, Elijah Raphael
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Abstract
BACKGROUND: The literature on fever related arrhythmic events (AE) in Brugada syndrome (BrS) is currently limited to few case reports and small series. OBJECTIVE: The current study aims to describe the characteristics of fever-related AE in a large cohort of BrS patients. METHODS: SABRUS is a multicenter study on 678 BrS patients with first AE documented at time of aborted cardiac arrest (ACA) (n=426) or after prophylactic ICD implantation (n=252). RESULTS: In 35(6%) of the 588 patients with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%) and proband (70%). Age at time of AE was 29±24 (range 0.3-76) years. Most patients (80%) presented with ACA and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope and spontaneous type 1 Brugada-ECG were noted in 17%, 40% and 66% of patients, respectively. VF was induced at EPS in 9/19(47%) patients. An SCN5A mutation was found in 14/28(50%) patients. The highest proportion of fever-related AE was observed in the pediatric population (age <16), with disproportionally higher event rate in the very young (0-5 years old) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged<24 years, but no Asians aged <24 years. CONCLUSIONS: The risk of fever-related AE in BrS markedly varies according to age group, gender and ethnicity. Taking these factors into account could help the clinical management of BrS patients with fever.
Item Type: | Article |
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Additional Information: | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Keywords: | Brugada syndrome, Fever, children, elderly, ethnicity, gender, 1102 Cardiovascular Medicine And Haematology, 0903 Biomedical Engineering |
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: | Heart Rhythm |
ISSN: | 1556-3871 |
Language: | eng |
Publisher License: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
PubMed ID: | 29649615 |
Go to PubMed abstract | |
URI: | https://openaccess.sgul.ac.uk/id/eprint/109749 |
Publisher's version: | https://doi.org/10.1016/j.hrthm.2018.04.007 |
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