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The current landscape of nucleic acid tests for filovirus detection.

Clark, DJ; Tyson, J; Sails, AD; Krishna, S; Staines, HM (2018) The current landscape of nucleic acid tests for filovirus detection. J Clin Virol, 103. pp. 27-36. ISSN 1873-5967 https://doi.org/10.1016/j.jcv.2018.03.005
SGUL Authors: Krishna, Sanjeev Staines, Henry Michael Clark, David John

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Abstract

Nucleic acid testing (NAT) for pathogenic filoviruses plays a key role in surveillance and to control the spread of infection. As they share clinical features with other pathogens, the initial spread of these viruses can be misdiagnosed. Tests that can identify a pathogen in the initial stages of infection are essential to control outbreaks. Since the Ebola virus disease (EVD) outbreak in 2014-2016 several tests have been developed that are faster than previous tests and more suited for field use. Furthermore, the ability to test for a range of pathogens simultaneously has been expanded to improve clinical pathway management of febrile syndromes. This review provides an overview of these novel diagnostic tests.

Item Type: Article
Additional Information: © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Keywords: Diagnostics, Ebola, Filoviridae, Marburg, NAT, Point-of-care, Diagnostics, Ebola, Filoviridae, Marburg, NAT, Point-of-care, 1103 Clinical Sciences, 0605 Microbiology, 1108 Medical Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: J Clin Virol
ISSN: 1873-5967
Language: eng
Dates:
DateEvent
June 2018Published
22 March 2018Published Online
14 March 2018Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
204809/Z/16/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 29625392
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109716
Publisher's version: https://doi.org/10.1016/j.jcv.2018.03.005

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