Gandra, S;
Alvarez-Uria, G;
Murki, S;
Singh, SK;
Kanithi, R;
Jinka, DR;
Chikkappa, AK;
Subramanian, S;
Sharma, A;
Dharmapalan, D;
et al.
Gandra, S; Alvarez-Uria, G; Murki, S; Singh, SK; Kanithi, R; Jinka, DR; Chikkappa, AK; Subramanian, S; Sharma, A; Dharmapalan, D; Kandraju, H; Vasudevan, AK; Tunga, O; Akula, A; Hsia, Y; Sharland, M; Laxminarayan, R
(2018)
Point prevalence surveys of antimicrobial use among eight neonatal intensive care units in India: 2016.
Int J Infect Dis, 71.
pp. 20-24.
ISSN 1878-3511
https://doi.org/10.1016/j.ijid.2018.03.017
SGUL Authors: Sharland, Michael Roy Hsia, Yingfen
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Abstract
BACKGROUND: Information about antimicrobial use is scarce and poorly understood among neonatal intensive care units (NICUs) in India. In this study, we describe antimicrobial use in eight NICUs using four point prevalence surveys (PPSs). METHODS: As part of the Global Antimicrobial Resistance, Prescribing, and Efficacy in Neonates and Children (GARPEC) study, one-day, cross-sectional, hospital-based PPSs were conducted four times between 1 February 2016 and 28 February 2017 in eight NICUs. Using a standardized web-based electronic data entry form, detailed data were collected for babies on antimicrobials. RESULTS: A total of 403 babies were admitted to NICUs across all survey days, and 208 (51.6%) were prescribed one or more antimicrobials. Among 208 babies, 155 (74.5%) were prescribed antimicrobials for treatment of an active infection. Among 155 babies with an active infection, treatment was empiric in 109 (70.3%). Sepsis (108, 49.1%) was the most common reason for prescribing antimicrobials. Amikacin (17%) followed by meropenem (12%) were the two most commonly prescribed antimicrobials. For community-acquired sepsis, piperacillin-tazobactam (17.5%) was the most commonly prescribed drug. A combination of ampicillin and gentamicin was prescribed in only two babies (5%). CONCLUSIONS: The recommended first-line antimicrobial agents, ampicillin and gentamicin, were rarely prescribed in Indian NICUs for community acquired neonatal sepsis.
Item Type: | Article | ||||||
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Additional Information: | © 2018 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | ||||||
Keywords: | India, NICU, antimicrobial use, neonates, point prevalence survey, Microbiology, 0605 Microbiology, 1108 Medical Microbiology | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | ||||||
Journal or Publication Title: | Int J Infect Dis | ||||||
ISSN: | 1878-3511 | ||||||
Language: | eng | ||||||
Publisher License: | Creative Commons: Attribution 4.0 | ||||||
Projects: |
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PubMed ID: | 29608958 | ||||||
Go to PubMed abstract | |||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/109686 | ||||||
Publisher's version: | https://doi.org/10.1016/j.ijid.2018.03.017 |
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