Sadnicka, A; Daum, C; Cordivari, C; Bhatia, KP; Rothwell, JC; Manohar, S; Edwards, MJ
(2017)
Mind the gap: temporal discrimination and dystonia.
Eur J Neurol, 24 (6).
pp. 796-806.
ISSN 1468-1331
https://doi.org/10.1111/ene.13293
SGUL Authors: Edwards, Mark John James Sadnicka, Anna
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Abstract
BACKGROUND AND PURPOSE: One of the most widely studied perceptual measures of sensory dysfunction in dystonia is the temporal discrimination threshold (TDT) (the shortest interval at which subjects can perceive that there are two stimuli rather than one). However the elevated thresholds described may be due to a number of potential mechanisms as current paradigms test not only temporal discrimination but also extraneous sensory and decision-making parameters. In this study two paradigms designed to better quantify temporal processing are presented and a decision-making model is used to assess the influence of decision strategy. METHODS: 22 patients with cervical dystonia and 22 age-matched controls completed two tasks (i) temporal resolution (a randomized, automated version of existing TDT paradigms) and (ii) interval discrimination (rating the length of two consecutive intervals). RESULTS: In the temporal resolution task patients had delayed (P = 0.021) and more variable (P = 0.013) response times but equivalent discrimination thresholds. Modelling these effects suggested this was due to an increased perceptual decision boundary in dystonia with patients requiring greater evidence before committing to decisions (P = 0.020). Patient performance on the interval discrimination task was normal. CONCLUSIONS: Our work suggests that previously observed abnormalities in TDT may not be due to a selective sensory deficit of temporal processing as decision-making itself is abnormal in cervical dystonia.
Item Type: | Article | |||||||||||||||
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Additional Information: | This is the peer reviewed version of the following article: Sadnicka, A., Daum, C., Cordivari, C., Bhatia, K.P., Rothwell, J.C., Manohar, S. and Edwards, M.J. (2017), Mind the gap: temporal discrimination and dystonia. Eur J Neurol, 24: 796-806, which has been published in final form at https://doi.org/10.1111/ene.13293. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||||||||||||
Keywords: | cervical dystonia, drift diffusion model, millisecond timing, psychophysics, temporal discrimination threshold, Adult, Aged, Discrimination, Psychological, Female, Humans, Male, Middle Aged, Reaction Time, Time Perception, Torticollis, Humans, Torticollis, Time Perception, Reaction Time, Adult, Aged, Middle Aged, Female, Male, Discrimination, Psychological, cervical dystonia, drift diffusion model, millisecond timing, psychophysics, temporal discrimination threshold, cervical dystonia, drift diffusion model, millisecond timing, psychophysics, temporal discrimination threshold, Neurology & Neurosurgery, 1103 Clinical Sciences, 1109 Neurosciences | |||||||||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) | |||||||||||||||
Journal or Publication Title: | Eur J Neurol | |||||||||||||||
ISSN: | 1468-1331 | |||||||||||||||
Language: | eng | |||||||||||||||
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Publisher License: | Publisher's own licence | |||||||||||||||
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PubMed ID: | 28544409 | |||||||||||||||
Web of Science ID: | WOS:000405348000009 | |||||||||||||||
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URI: | https://openaccess.sgul.ac.uk/id/eprint/109498 | |||||||||||||||
Publisher's version: | https://doi.org/10.1111/ene.13293 |
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