Elhakeem, A; Murray, ET; Cooper, R; Kuh, D; Whincup, P; Hardy, R
(2018)
Leisure-time physical activity across adulthood and biomarkers of cardiovascular disease at age 60-64: A prospective cohort study.
Atherosclerosis, 269.
pp. 279-287.
ISSN 1879-1484
https://doi.org/10.1016/j.atherosclerosis.2017.11.019
SGUL Authors: Whincup, Peter Hynes
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Abstract
BACKGROUND AND AIMS: This study examined associations between leisure-time physical activity (LTPA) across adulthood (from age 36) and cardiovascular disease (CVD) biomarkers at age 60-64. METHODS: LTPA was reported by study participants from the MRC National Survey of Health and Development at ages 36, 43, 53 and 60-64 (n = 1754) and categorised as inactive, moderately active (1-4/month) or most active (5+/month) at each age. Linear regression was used to examine associations between a cumulative adulthood LTPA score (range = 0-8), and change in LTPA between ages 36 and 60-64 (i.e. always inactive, became inactive, became active, always active) and inflammatory [C-reactive protein (CRP), interleukin-6 (IL-6)], endothelial [tissue-Plasminogen Activator (t-PA), E-selectin] and adipokine [leptin, adiponectin] measures extracted from overnight fasting blood samples at age 60-64. RESULTS: The more active a participant was over adulthood, the better their biomarker profile, e.g. fully-adjusted difference in t-PA (both sexes) and adiponectin (women) per unit increase in the LTPA score (95% confidence interval) = -2.2% (-3.6; -0.8) and 2.0% (0.2; 3.8). Those that became active at age 60-64 showed slightly healthier biomarker profiles than those that became inactive [e.g. fully-adjusted difference in IL-6 = -9.9% (-23.9; 4.1) vs. -3.8% (-12.4; 4.8)], although the best profiles were seen for those always active [IL-6: -15.0% (-24.2; -5.7)], when compared with the always inactive group. CONCLUSIONS: Greater accumulation of LTPA across adulthood was associated with a more favourable CVD biomarker profile in early old age. Earlier uptake and long-term maintenance of LTPA may provide the greatest benefits for CVD prevention.
Item Type: | Article | |||||||||
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Additional Information: | © 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | |||||||||
Keywords: | Atherosclerosis, Biomarkers, Cardiovascular disease, Exercise, Physical activity, Atherosclerosis, Biomarkers, Cardiovascular disease, Exercise, Physical activity, 1103 Clinical Sciences, 1102 Cardiovascular Medicine And Haematology | |||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Population Health Research Institute (INPH) | |||||||||
Journal or Publication Title: | Atherosclerosis | |||||||||
ISSN: | 1879-1484 | |||||||||
Language: | eng | |||||||||
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Publisher License: | Creative Commons: Attribution 4.0 | |||||||||
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PubMed ID: | 29180005 | |||||||||
Go to PubMed abstract | ||||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/109447 | |||||||||
Publisher's version: | https://doi.org/10.1016/j.atherosclerosis.2017.11.019 |
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