Seale, AC;
Bianchi-Jassir, F;
Russell, NJ;
Kohli-Lynch, M;
Tann, CJ;
Hall, J;
Madrid, L;
Blencowe, H;
Cousens, S;
Baker, CJ;
et al.
Seale, AC; Bianchi-Jassir, F; Russell, NJ; Kohli-Lynch, M; Tann, CJ; Hall, J; Madrid, L; Blencowe, H; Cousens, S; Baker, CJ; Bartlett, L; Cutland, C; Gravett, MG; Heath, PT; Ip, M; Le Doare, K; Madhi, SA; Rubens, CE; Saha, SK; Schrag, SJ; Sobanjo-Ter Meulen, A; Vekemans, J; Lawn, JE
(2017)
Estimates of the Burden of Group B Streptococcal Disease Worldwide for Pregnant Women, Stillbirths, and Children.
Clin Infect Dis, 65 (suppl_2).
S200-S219.
ISSN 1537-6591
https://doi.org/10.1093/cid/cix664
SGUL Authors: Heath, Paul Trafford Le Doare, Kirsty
Abstract
Background: We aimed to provide the first comprehensive estimates of the burden of group B Streptococcus (GBS), including invasive disease in pregnant and postpartum women, fetal infection/stillbirth, and infants. Intrapartum antibiotic prophylaxis is the current mainstay of prevention, reducing early-onset infant disease in high-income contexts. Maternal GBS vaccines are in development. Methods: For 2015 live births, we used a compartmental model to estimate (1) exposure to maternal GBS colonization, (2) cases of infant invasive GBS disease, (3) deaths, and (4) disabilities. We applied incidence or prevalence data to estimate cases of maternal and fetal infection/stillbirth, and infants with invasive GBS disease presenting with neonatal encephalopathy. We applied risk ratios to estimate numbers of preterm births attributable to GBS. Uncertainty was also estimated. Results: Worldwide in 2015, we estimated 205000 (uncertainty range [UR], 101000-327000) infants with early-onset disease and 114000 (UR, 44000-326000) with late-onset disease, of whom a minimum of 7000 (UR, 0-19000) presented with neonatal encephalopathy. There were 90000 (UR, 36000-169000) deaths in infants <3 months age, and, at least 10000 (UR, 3000-27000) children with disability each year. There were 33000 (UR, 13000-52000) cases of invasive GBS disease in pregnant or postpartum women, and 57000 (UR, 12000-104000) fetal infections/stillbirths. Up to 3.5 million preterm births may be attributable to GBS. Africa accounted for 54% of estimated cases and 65% of all fetal/infant deaths. A maternal vaccine with 80% efficacy and 90% coverage could prevent 107000 (UR, 20000-198000) stillbirths and infant deaths. Conclusions: Our conservative estimates suggest that GBS is a leading contributor to adverse maternal and newborn outcomes, with at least 409000 (UR, 144000-573000) maternal/fetal/infant cases and 147000 (UR, 47000-273000) stillbirths and infant deaths annually. An effective GBS vaccine could reduce disease in the mother, the fetus, and the infant.
Item Type: |
Article
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Additional Information: |
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: |
group B Streptococcus, infection, maternal, newborn, stillbirth, group B Streptococcus, infection, newborn, stillbirth, maternal, Microbiology, 06 Biological Sciences, 11 Medical And Health Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Clin Infect Dis |
ISSN: |
1537-6591 |
Language: |
eng |
Dates: |
Date | Event |
---|
15 November 2017 | Published | 6 November 2017 | Published Online |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
|
PubMed ID: |
29117332 |
Web of Science ID: |
WOS:000414511400011 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/109347 |
Publisher's version: |
https://doi.org/10.1093/cid/cix664 |
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