Sadnicka, A; Kornysheva, K; Rothwell, JC; Edwards, MJ
(2018)
A unifying motor control framework for task-specific dystonia.
Nat Rev Neurol, 14 (2).
pp. 116-124.
ISSN 1759-4766
https://doi.org/10.1038/nrneurol.2017.146
SGUL Authors: Sadnicka, Anna
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Abstract
Task-specific dystonia is a movement disorder characterized by a painless loss of dexterity specific to a particular motor skill. This disorder is prevalent among writers, musicians, dancers and athletes. No current treatment is predictably effective, and the disorder generally ends the careers of affected individuals. Traditional disease models of dystonia have a number of limitations with regard to task-specific dystonia. We therefore discuss emerging evidence that the disorder has its origins within normal compensatory mechanisms of a healthy motor system in which the representation and reproduction of motor skill are disrupted. We describe how risk factors for task-specific dystonia can be stratified and translated into mechanisms of dysfunctional motor control. The proposed model aims to define new directions for experimental research and stimulate therapeutic advances for this highly disabling disorder.
Item Type: | Article | |||||||||
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Additional Information: | © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. | |||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Neuroscience (INCCNS) |
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Journal or Publication Title: | Nat Rev Neurol | |||||||||
ISSN: | 1759-4766 | |||||||||
Language: | eng | |||||||||
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Publisher License: | Publisher's own licence | |||||||||
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PubMed ID: | 29104291 | |||||||||
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URI: | https://openaccess.sgul.ac.uk/id/eprint/109319 | |||||||||
Publisher's version: | https://doi.org/10.1038/nrneurol.2017.146 |
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