Caissutti, C; Familiari, A; Khalil, A; Flacco, ME; Manzoli, L; Scambia, G; Cagnacci, A; D'Antonio, F
(2018)
Small fetal thymus and adverse obstetrical outcome: a systematic review and a meta-analysis.
Acta Obstet Gynecol Scand, 97 (2).
pp. 111-121.
ISSN 1600-0412
https://doi.org/10.1111/aogs.13249
SGUL Authors: Khalil, Asma
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Abstract
INTRODUCTION: To explore the association between small fetal thymus on ultrasound and adverse obstetrical outcome. MATERIAL AND METHODS: Medline, Embase, Cochrane and Web of Science databases were searched. Primary outcome was the risk of preterm birth before 37 and 34 weeks in fetuses with compared to those without a small thymus on ultrasound. SECONDARY OUTCOMES: occurrence of chorioamnionitis, intra-uterine growth restriction, neonatal sepsis, gestational age at birth, birthweight, neonatal morbidity and pre-eclampsia. RESULTS: Twelve studies including 1744 fetuses who had ultrasound assessment of thymus during pregnancy were included. Women with preterm premature rupture of the membranes (PPROM) or with preterm labour with a small fetal thymus were at higher risk of preterm birth <37 (p= 0.01), <34 (12.5 (p<0.001) weeks in fetuses with compared to those without small thymus, and the risk of chorioamnionitis was higher when the thymus was small (p<0.001). Fetuses with small thymus were not at higher risk of intra-uterine growth restriction (p= 0.3). A small thymus increased the risk of neonatal sepsis (p= 0.007) and morbidity (p= 0.003), but not the risk of pre-eclampsia (p= 0.9). CONCLUSIONS: A small fetal thymus is associated with a higher risk of preterm birth, chorioamnionitis, neonatal sepsis and morbidity, but not with intra-uterine growth restriction and pre-eclampsia. This article is protected by copyright. All rights reserved.
Item Type: |
Article
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Additional Information: |
This is the peer reviewed version of the following article: Caissutti C, Familiari A, Khalil A, Flacco ME, Manzoli L, Scambia G, et al. Small fetal thymus and adverse obstetrical outcome: a systematic review and a meta-analysis. Acta Obstet Gynecol Scand 2018; 97:111–121., which has been published in final form at http://doi.org/10.1111/aogs.13249. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: |
Fetal thymus, chorioamnionitis, fetal monitoring, high risk pregnancy, infections, intra-uterine growth restriction, neonatal sepsis, outcome, pre-eclampsia, prenatal diagnosis, preterm birth, ultrasound, Obstetrics & Reproductive Medicine, 1114 Paediatrics And Reproductive Medicine, 1117 Public Health And Health Services |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Acta Obstet Gynecol Scand |
ISSN: |
1600-0412 |
Language: |
eng |
Dates: |
Date | Event |
---|
22 January 2018 | Published | 6 December 2017 | Published Online | 10 October 2017 | Accepted |
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Publisher License: |
Publisher's own licence |
PubMed ID: |
29057456 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/109255 |
Publisher's version: |
https://doi.org/10.1111/aogs.13249 |
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