Moon, RJ;
Harvey, NC;
Cooper, C;
D'Angelo, S;
Crozier, SR;
Inskip, HM;
Schoenmakers, I;
Prentice, A;
Arden, NK;
Bishop, NJ;
et al.
Moon, RJ; Harvey, NC; Cooper, C; D'Angelo, S; Crozier, SR; Inskip, HM; Schoenmakers, I; Prentice, A; Arden, NK; Bishop, NJ; Carr, A; Dennison, EM; Eastell, R; Fraser, R; Gandhi, SV; Godfrey, KM; Kennedy, S; Mughal, MZ; Papageorghiou, AT; Reid, DM; Robinson, SM; Javaid, MK
(2016)
Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation During Pregnancy.
J Clin Endocrinol Metab, 101 (12).
pp. 5012-5020.
ISSN 1945-7197
https://doi.org/10.1210/jc.2016-2869
SGUL Authors: Papageorghiou, Aris
Abstract
CONTEXT: Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response. OBJECTIVE: We assessed which maternal and environmental characteristics were associated with 25(OH)D after supplementation with cholecalciferol. DESIGN: Within-randomization-group analysis of participants in the Maternal Vitamin D Osteoporosis Study trial of vitamin D supplementation in pregnancy. SETTING: Hospital antenatal clinics. PARTICIPANTS: A total of 829 pregnant women (422 placebo, 407 cholecalciferol). At 14 and 34 weeks of gestation, maternal anthropometry, health, and lifestyle were assessed and 25(OH)D measured. Compliance was determined using pill counts at 19 and 34 weeks. INTERVENTIONS: 1000 IU/d of cholecalciferol or matched placebo from 14 weeks of gestation until delivery. MAIN OUTCOME MEASURE: 25(OH)D at 34 weeks, measured in a single batch (Diasorin Liaison). RESULTS: 25(OH)D at 34 weeks of gestation was higher in the women randomized to vitamin D (mean [SD], 67.7 [21.3] nmol/L) compared with placebo (43.1 [22.5] nmol/L; P < .001). In women randomized to cholecalciferol, higher pregnancy weight gain from 14 to 34 weeks of gestation (kg) (β = -0.81 [95% confidence interval -1.39, -0.22]), lower compliance with study medication (%) (β = -0.28 [-0.072, -0.48]), lower early pregnancy 25(OH)D (nmol/L) (β = 0.28 [0.16, 0.40]), and delivery in the winter vs the summer (β = -10.5 [-6.4, -14.6]) were independently associated with lower 25(OH)D at 34 weeks of gestation. CONCLUSIONS: Women who gained more weight during pregnancy had lower 25(OH)D in early pregnancy and delivered in winter achieved a lower 25(OH)D in late pregnancy when supplemented with 1000 IU/d cholecalciferol. Future studies should aim to determine appropriate doses to enable consistent repletion of 25(OH)D during pregnancy.
Item Type: |
Article
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Additional Information: |
This article has been published under the terms of the Creative Commons Attribution License(CC-BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). |
Keywords: |
Adult, Cholecalciferol, Double-Blind Method, Female, Humans, Outcome Assessment (Health Care), Pregnancy, Pregnancy Trimesters, Seasons, Vitamin D, Vitamins, Weight Gain, Young Adult, Endocrinology & Metabolism, 1103 Clinical Sciences, 1114 Paediatrics And Reproductive Medicine |
SGUL Research Institute / Research Centre: |
Academic Structure > Institute of Medical & Biomedical Education (IMBE) Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE ) |
Journal or Publication Title: |
J Clin Endocrinol Metab |
ISSN: |
1945-7197 |
Language: |
eng |
Dates: |
Date | Event |
---|
1 December 2016 | Published | 28 October 2016 | Published Online | 3 October 2016 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
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PubMed ID: |
27788053 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/109169 |
Publisher's version: |
https://doi.org/10.1210/jc.2016-2869 |
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