SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Sleep Duration and Risk of Type 2 Diabetes.

Rudnicka, AR; Nightingale, CM; Donin, AS; Sattar, N; Cook, DG; Whincup, PH; Owen, CG (2017) Sleep Duration and Risk of Type 2 Diabetes. Pediatrics, 140 (3). e20170338. ISSN 1098-4275 https://doi.org/10.1542/peds.2017-0338
SGUL Authors: Rudnicka, Alicja Regina Nightingale, Claire Donin, Angela Cook, Derek Gordon Whincup, Peter Hynes Owen, Christopher Grant

[img] Microsoft Word (.docx) Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (130kB)
[img]
Preview
PDF (Figure 1) Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (2kB) | Preview
[img]
Preview
PDF (Figure 2) Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (32kB) | Preview
[img]
Preview
PDF (Supplementary Figure 1) Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (6kB) | Preview

Abstract

BACKGROUND: Associations between sleep duration and type 2 diabetes (T2D) risk markers in childhood have been little studied. We examined associations between self-reported sleep duration and T2D risk markers in children. METHODS: Cross-sectional study of 4525 multiethnic UK children aged 9 to 10 years. Sleep time was calculated from self-reported usual time of going to bed and getting up on a school day, validated in a subset using accelerometers. Fasting blood samples provided levels of serum lipids and insulin, plasma glucose, and HbA1c. Physical measures included height, weight, bioimpedance, and blood pressure. Multilevel linear regression models of anthropometric, T2D, and cardiovascular risk markers with sleep duration were adjusted for sex, age, month, ethnicity, socioeconomic position, observer (physical measures only), and random effect of school. RESULTS: On average, children slept 10.5 hours per night (95% range 8.0-12.0 hours). There were strong inverse graded relationships between sleep duration, adiposity, and diabetes risk markers. In adjusted models, a 1-hour-longer sleep duration was associated with 0.19 lower BMI (95% confidence interval [CI] 0.09 to 0.28), 0.03 kg/m(5) lower fat mass index (95% CI 0.00 to 0.05 kg/m(5)), 2.9% lower homeostasis model assessment insulin resistance (95% CI 1.2% to 4.4%), and 0.24% lower fasting glucose (95% CI 0.03% to 0.44%); there was no association with HbA1c or cardiovascular risk. Associations with insulin and glucose remained after an additional adjustment for adiposity markers. CONCLUSIONS: The finding of an inverse association between sleep duration and T2D risk markers in childhood is novel. Intervention studies are needed to establish the causality of these associations, which could provide a simple strategy for early T2D prevention.

Item Type: Article
Additional Information: Copyright © 2017 by the American Academy of Pediatrics
Keywords: Pediatrics, 11 Medical And Health Sciences, 17 Psychology And Cognitive Sciences
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Pediatrics
ISSN: 1098-4275
Language: eng
Dates:
DateEvent
1 September 2017Published
12 May 2017Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
068362/Z/02/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
PG/06/003British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
UNSPECIFIEDCancer Research UKhttp://dx.doi.org/10.13039/501100000289
UNSPECIFIEDEconomic and Social Research Councilhttp://dx.doi.org/10.13039/501100000269
UNSPECIFIEDMedical Research Councilhttp://dx.doi.org/10.13039/501100000265
PubMed ID: 28811317
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109140
Publisher's version: https://doi.org/10.1542/peds.2017-0338

Statistics

Item downloaded times since 12 Jun 2018.

Actions (login required)

Edit Item Edit Item