Ball, G;
Aljabar, P;
Nongena, P;
Kennea, N;
Gonzalez-Cinca, N;
Falconer, S;
Chew, ATM;
Harper, N;
Wurie, J;
Rutherford, MA;
et al.
Ball, G; Aljabar, P; Nongena, P; Kennea, N; Gonzalez-Cinca, N; Falconer, S; Chew, ATM; Harper, N; Wurie, J; Rutherford, MA; Counsell, SJ; Edwards, AD
(2017)
Multimodal image analysis of clinical influences on preterm brain development.
Ann Neurol, 82 (2).
pp. 233-246.
ISSN 1531-8249
https://doi.org/10.1002/ana.24995
SGUL Authors: Kennea, Nigel
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Abstract
OBJECTIVE: Premature birth is associated with numerous complex abnormalities of white and gray matter and a high incidence of long-term neurocognitive impairment. An integrated understanding of these abnormalities and their association with clinical events is lacking. The aim of this study was to identify specific patterns of abnormal cerebral development and their antenatal and postnatal antecedents. METHODS: In a prospective cohort of 449 infants (226 male), we performed a multivariate and data-driven analysis combining multiple imaging modalities. Using canonical correlation analysis, we sought separable multimodal imaging markers associated with specific clinical and environmental factors and correlated to neurodevelopmental outcome at 2 years. RESULTS: We found five independent patterns of neuroanatomical variation that related to clinical factors including age, prematurity, sex, intrauterine complications, and postnatal adversity. We also confirmed the association between imaging markers of neuroanatomical abnormality and poor cognitive and motor outcomes at 2 years. INTERPRETATION: This data-driven approach defined novel and clinically relevant imaging markers of cerebral maldevelopment, which offer new insights into the nature of preterm brain injury. Ann Neurol 2017;82:233-246.
Item Type: | Article | |||||||||
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Additional Information: | © 2017 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |||||||||
Keywords: | Neurology & Neurosurgery, 1103 Clinical Sciences, 1109 Neurosciences | |||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Institute of Medical, Biomedical and Allied Health Education (IMBE) Academic Structure > Institute of Medical, Biomedical and Allied Health Education (IMBE) > Centre for Clinical Education (INMECE ) |
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Journal or Publication Title: | Ann Neurol | |||||||||
ISSN: | 1531-8249 | |||||||||
Language: | eng | |||||||||
Publisher License: | Creative Commons: Attribution 4.0 | |||||||||
Projects: |
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PubMed ID: | 28719076 | |||||||||
Web of Science ID: | WOS:000408080300008 | |||||||||
Go to PubMed abstract | ||||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/109113 | |||||||||
Publisher's version: | https://doi.org/10.1002/ana.24995 |
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