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In utero exposure to malaria is associated with metabolic traits in adolescence: The Agogo 2000 birth cohort study.

Bedu-Addo, G; Alicke, M; Boakye-Appiah, JK; Abdul-Jalil, I; van der Giet, M; Schulze, MB; Mockenhaupt, FP; Danquah, I (2017) In utero exposure to malaria is associated with metabolic traits in adolescence: The Agogo 2000 birth cohort study. J Infect, 75 (5). pp. 455-463. ISSN 1532-2742 https://doi.org/10.1016/j.jinf.2017.08.010
SGUL Authors: Boakye-Appiah, Justice Kofi

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Abstract

OBJECTIVES: Malaria in pregnancy (MiP) contributes to fetal undernutrition and adverse birth outcomes, and may constitute a developmental origin of metabolic diseases in the offspring. In a Ghanaian birth cohort, we examined the relationships between MiP-exposure and metabolic traits in adolescence. METHODS: MiP at delivery was assessed in 155 mother-child pairs. Among the now teenaged children (mean age, 14.8 years; 53% male), we measured fasting plasma glucose (FPG), body mass index (BMI), and systolic and diastolic blood pressure (BP). Associations of MiP with the adolescents' FPG, BMI, and BP were examined by linear regression. RESULTS: At delivery, 45% were MiP-exposed, which increased FPG in adolescence, adjusted for mother's age at delivery, parity and familial socio-economic status (infected vs. uninfected: mean ΔFPG = 0.20 mmol/L; 95% confidence interval (CI): 0.01, 0.39; p = 0.049). As a trend,this was discernible for BP, particularly for microscopic infections (mean Δsystolic BP = 5.43 mmHg; 95% CI: 0.00, 10.88; p = 0.050; mean Δdiastolic BP = 3.67 mmHg; 95% CI: -0.81, 8.14; p = 0.107). These associations were largely independent of birth weight, gestational age and teenage BMI. Adolescent BMI was not related to MiP. CONCLUSIONS: In rural Ghana, exposure to malaria during fetal development contributes to metabolic conditions in young adulthood.

Item Type: Article
Additional Information: © 2017 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Ghana, Hypertension, Malaria in pregnancy, Obesity, Type 2 diabetes, Ghana, Hypertension, Malaria in pregnancy, Obesity, Type 2 diabetes, Microbiology, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: J Infect
ISSN: 1532-2742
Language: eng
Dates:
DateEvent
November 2017Published
26 August 2017Published Online
18 August 2017Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 28851533
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109112
Publisher's version: https://doi.org/10.1016/j.jinf.2017.08.010

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