Holt, CT; Hitchings, AW
(2017)
Drug-induced metabolic acidosis.
Adverse Drug Reaction Bulletin, 304 (1).
pp. 1176-1178.
ISSN 0044-6394
https://doi.org/10.1097/FAD.0000000000000025
SGUL Authors: Hitchings, Andrew William
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Abstract
Summary: Drug causes of metabolic acidosis are numerous and their mechanisms are diverse. Broadly, they can cause metabolic acidosis with either a normal anion gap (e.g. drug-induced renal tubular acidosis) or an elevated anion gap (e.g. drug-induced lactic acidosis or pyroglutamic acidosis). This review describes the drugs that can cause or contribute to metabolic acidosis during therapeutic use, the mechanisms by which this occurs, and how they may be identified in practice.
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