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Diabetes and poor tuberculosis treatment outcomes: issues and implications in data interpretation and analysis

Huangfu, P; Pearson, F; Ugarte-Gil, C; Critchley, J (2017) Diabetes and poor tuberculosis treatment outcomes: issues and implications in data interpretation and analysis. International Journal of Tuberculosis and Lung Disease (IJTLD), 21 (12). pp. 1214-1219. ISSN 1027-3719 https://doi.org/10.5588/ijtld.17.0211
SGUL Authors: Critchley, Julia Pearson, Fiona Huangfu, Peijue

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Abstract

Tuberculosis (TB) remains one of the 10 leading causes of death worldwide, especially in low- and middle-income countries. We conducted a systematic review and meta-analysis including 88 studies examining the association between diabetes mellitus (DM) and TB treatment outcomes. However, we found several common methodological problems among them, including inappropriate adjustments for confounding factors, not using optimal statistical methods for ‘time to event' data, misclassification in exposure (DM) and outcomes (TB treatment outcomes) due to study design and non-standardisation of definitions, misunderstanding of basic study design concept, standardisation of TB treatment outcomes and quality control of publications. Many of these problems would apply more broadly to other ‘risk factors' for poor TB treatment outcomes. These issues need to be addressed and resolved to improve the quality of the studies and provide more accurate results for policy makers in the future to tackle the burden of TB.

Item Type: Article
Additional Information: © Copyright 2017 International Journal of Tuberculosis and Lung Disease (IJTLD)
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: International Journal of Tuberculosis and Lung Disease (IJTLD)
ISSN: 1027-3719
Dates:
DateEvent
1 December 2017Published
23 August 2017Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
7-627-3-167Qatar Foundationhttp://dx.doi.org/10.13039/100007458
D43TW00976301National Institute of HealthUNSPECIFIED
URI: https://openaccess.sgul.ac.uk/id/eprint/109093
Publisher's version: https://doi.org/10.5588/ijtld.17.0211

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