Scholz, H; Eder, C
(2017)
Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes.
J Neuroimmunol, 310.
pp. 107-110.
ISSN 1872-8421
https://doi.org/10.1016/j.jneuroim.2017.07.004
SGUL Authors: Eder, Claudia
Abstract
Inflammasomes regulate microglial caspase-1 activation and subsequent neuroinflammatory processes in brain pathology. In the present study, we have identified inflammasomes causing caspase-1 activation following stimulation of microglia with lysophosphatidylcholine (LPC), a proinflammatory lipid generated under pathological conditions in the brain. LPC-induced caspase-1 activation in microglia was found to depend on LPS prestimulation, inflammasome NLRP3 and adaptor molecule ASC. Furthermore, knockdown of inflammasome NLRC4 inhibited LPC-stimulated caspase-1 activity in microglia, suggesting the requirement of two inflammasomes for optimal caspase-1 activity.
| Item Type: |
Article
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| Additional Information: |
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: |
Caspase-1, Inflammasome, Lysophospholipids, Microglia, Caspase-1, Inflammasome, Lysophospholipids, Microglia, Neurology & Neurosurgery, 1107 Immunology, 1109 Neurosciences |
| SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
| Journal or Publication Title: |
J Neuroimmunol |
| ISSN: |
1872-8421 |
| Language: |
eng |
| Dates: |
| Date | Event |
|---|
| 15 September 2017 | Published | | 10 July 2017 | Published Online | | 8 July 2017 | Accepted |
|
| Publisher License: |
Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
| Projects: |
|
| PubMed ID: |
28778433 |
 |
Go to PubMed abstract |
| URI: |
https://openaccess.sgul.ac.uk/id/eprint/109057 |
| Publisher's version: |
https://doi.org/10.1016/j.jneuroim.2017.07.004 |
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