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Beaty, TH;
Becker, AB;
Beilby, J;
et al.
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(2018)
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Nat Genet, 50 (1).
pp. 42-53.
ISSN 1546-1718
https://doi.org/10.1038/s41588-017-0014-7
SGUL Authors: Strachan, David Peter
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Abstract
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
| Item Type: | Article | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Additional Information: | This is a post-peer-review, pre-copyedit version of an article published in Nature Genetics. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41588-017-0014-7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Keywords: | Developmental Biology, 11 Medical And Health Sciences, 06 Biological Sciences | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Population Health Research Institute (INPH) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Nat Genet | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1546-1718 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Language: | eng | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Publisher License: | Publisher's own licence | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| PubMed ID: | 29273806 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Web of Science ID: | WOS:000423157400008 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/109029 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Publisher's version: | https://doi.org/10.1038/s41588-017-0014-7 |
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