Ciliberti, G; Seshasai, SRK; Ambrosio, G; Kaski, JC
(2017)
Safety of intracoronary provocative testing for the diagnosis of coronary artery spasm.
Int J Cardiol, 244.
pp. 77-83.
ISSN 1874-1754
https://doi.org/10.1016/j.ijcard.2017.05.109
SGUL Authors: Kaski, Juan Carlos
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Abstract
AIMS: Systematic review of literature to evaluate safety of intracoronary (i.c.) pharmacologic testing with acetylcholine (ACh), or ergonovine (ERGO), to induce coronary artery spasm. METHODS AND RESULTS: Review of all relevant publications using MEDLINE and EMBASE databases yielded 10 publications, totalling 9,444 patients. Prevalence of provoked spasm varied from 2.3% to 54.7% of patients tested in the selected studies. The wide variability in prevalence was due to heterogeneity of study populations and provocation protocols. No deaths were reported. Overall occurrence of major (0.8%) and minor (4.7%) complications for i.c. pharmacologic testing was low. Compared to ERGO, ACh showed significantly higher rate of major (1.09% vs 0.15%; p<0.001) and minor complications (5.87% vs 2.36%; p<0.001). CONCLUSION: Provocative testing with i.c. ACh or ERGO are safe and can facilitate the diagnosis of inducible coronary artery spasm during diagnostic coronary angiography. These tests should be part of the routine armamentarium of interventional cardiologists.
Item Type: | Article | ||||||||
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Additional Information: | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | ||||||||
Keywords: | Acetylcholine, Coronary artery spasm, Ergonovine, Microvascular constriction, Coronary artery spasm, Acetylcholine, Ergonovine, Microvascular constriction, Acetylcholine, Coronary artery spasm, Ergonovine, Microvascular constriction, Cardiovascular System & Hematology, 1102 Cardiovascular Medicine And Haematology | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) | ||||||||
Journal or Publication Title: | Int J Cardiol | ||||||||
ISSN: | 1874-1754 | ||||||||
Language: | eng | ||||||||
Dates: |
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Publisher License: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | ||||||||
PubMed ID: | 28622945 | ||||||||
Web of Science ID: | WOS:000406943600013 | ||||||||
Go to PubMed abstract | |||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/108982 | ||||||||
Publisher's version: | https://doi.org/10.1016/j.ijcard.2017.05.109 |
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