Sahoo, S; Meijles, DN; Pagano, PJ
(2016)
NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?
Clin Sci (Lond), 130 (5).
pp. 317-335.
ISSN 1470-8736
https://doi.org/10.1042/CS20150087
SGUL Authors: Meijles, Daniel Nathan
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Abstract
Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial fibrillation (AF). NADPH oxidases (Nox) are a major source of ROS in the vasculature and are key players in mediating redox signalling under physiological and pathophysiological conditions. In this review, we focus on the Nox-mediated ROS signalling pathways involved in the regulation of 'longevity genes' and recapitulate their role in age-associated vascular changes and in the development of age-related cardiovascular diseases (CVDs). This review is predicated on burgeoning knowledge that Nox-derived ROS propagate tightly regulated yet varied signalling pathways, which, at the cellular level, may lead to diminished repair, the aging process and predisposition to CVDs. In addition, we briefly describe emerging Nox therapies and their potential in improving the health of the elderly population.
Item Type: |
Article
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Additional Information: |
This is the accepted manuscript of an article published in Clinical Science. The final published version is located at https://doi.org/10.1042/CS20150087 |
Keywords: |
Aging, NADPH oxidase, aging, cardiovascular diseases, hypertension, oxidative stress, reduced nicotinamide–adenine dinucleotide phosphate (NADPH) oxidase, reduced nicotinamide–adenine dinucleotide phosphate oxidase therapeutics (Nox therapeutics), signalling pathway, Aging, Cardiovascular Agents, Cardiovascular Diseases, Humans, Molecular Targeted Therapy, NADPH Oxidases, Oxidation-Reduction, Oxidative Stress, Signal Transduction, Humans, Cardiovascular Diseases, NADPH Oxidase, Cardiovascular Agents, Signal Transduction, Oxidation-Reduction, Oxidative Stress, Aging, Molecular Targeted Therapy, aging, cardiovascular diseases, reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase, reduced nicotinamide-adenine dinucleotide phosphate oxidase therapeutics (Nox therapeutics), 11 Medical And Health Sciences, Cardiovascular System & Hematology |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Clin Sci (Lond) |
ISSN: |
1470-8736 |
Language: |
eng |
Dates: |
Date | Event |
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March 2016 | Published | 26 January 2016 | Published Online | 12 November 2015 | Accepted |
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Publisher License: |
Publisher's own licence |
Projects: |
Project ID | Funder | Funder ID |
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R01HL079207 | NHLBI NIH HHS | UNSPECIFIED | P01 HL103455 | NHLBI NIH HHS | UNSPECIFIED | R01 HL112914 | NHLBI NIH HHS | UNSPECIFIED | P01HL103455 | NHLBI NIH HHS | UNSPECIFIED | R01 HL079207 | NHLBI NIH HHS | UNSPECIFIED |
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PubMed ID: |
26814203 |
Web of Science ID: |
WOS:000369718400002 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/108892 |
Publisher's version: |
https://doi.org/10.1042/CS20150087 |
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