Morales-Roselló, J; Khalil, A; Fornés-Ferrer, V; Alberola-Rubio, J; Hervas-Marín, D; Peralta Llorens, N; Perales-Marín, A
(2017)
Progression of Doppler changes in early-onset small for gestational age fetuses. How frequent are the different progression sequences?
J Matern Fetal Neonatal Med, 31 (8).
pp. 1000-1008.
ISSN 1476-4954
https://doi.org/10.1080/14767058.2017.1304910
SGUL Authors: Khalil, Asma
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Abstract
OBJECTIVE: To evaluate the progression of Doppler abnormalities in early-onset fetal smallness (SGA). METHODS: A total of 948 Doppler examinations of the umbilical artery (UA), middle cerebral artery (MCA) and ductus venosus (DV), belonging to 405 early-onset SGA fetuses, were studied, evaluating the sequences of Doppler progression, the interval examination-labor at which Doppler became abnormal and the cumulative sum of Doppler anomalies in relation with labor proximity. RESULTS: The most frequent sequences were that in which only the UA pulsatility index (PI) became abnormal (42.1%) and that in which an abnormal UA PI appeared first, followed by an abnormal MCA PI (24.2%). In general, 71.3% of the fetuses followed the classical progression sequence UA→MCA→DV, mostly in the early stages of growth restriction (84.1%). In addition, the UA PI was the first parameter to be affected (9 weeks before delivery), followed by the MCA PI and the DV PIV (1 and 0 weeks). Finally, the UA PI began to sum anomalies 5 weeks before delivery, while the MCA and DV did it at 3 and 1 weeks before the pregnancy ended. CONCLUSIONS: In early-onset SGA fetuses, Doppler progression tends to follow a predictable order, with sequential changes in the umbilical, cerebral and DV impedances.
Item Type: | Article |
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Additional Information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Maternal-Fetal and Neonatal Medicine on 27/3/2017, available online: http://www.tandfonline.com/10.1080/14767058.2017.1304910 |
Keywords: | Early-onset fetal growth restriction, ductus venosus, fetal hemodynamics, fetal middle cerebral artery, small-for-gestational-age, umbilical artery, Obstetrics & Reproductive Medicine, 1114 Paediatrics And Reproductive Medicine |
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: | J Matern Fetal Neonatal Med |
ISSN: | 1476-4954 |
Language: | eng |
Publisher License: | Publisher's own licence |
PubMed ID: | 28279117 |
Go to PubMed abstract | |
URI: | https://openaccess.sgul.ac.uk/id/eprint/108882 |
Publisher's version: | https://doi.org/10.1080/14767058.2017.1304910 |
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