Lesscher, HMB; Bailey, A; Vanderschuren, LJMJ
(2017)
Genetic variability in adenosine deaminase-like contributes to variation in alcohol preference in mice.
Alcohol Clin Exp Res, 41 (7).
pp. 1271-1279.
ISSN 1530-0277
https://doi.org/10.1111/acer.13409
SGUL Authors: Bailey, Alexis
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Abstract
BACKGROUND: A substantial part of the risk for alcohol use disorder (AUD) is determined by genetic factors. We previously used chromosome substitution (CSS) mice, to identify a QTL for alcohol preference on mouse chromosome 2. The aim of this study was to identify candidate genes within this QTL that confer the risk for alcohol preference. METHODS: In order to delineate the neurobiological underpinnings of alcohol consumption, we expanded on the QTL approach to identify candidate genes for high alcohol preference in mice. We narrowed down a QTL for alcohol preference on mouse chromosome 2, that we previously identified using chromosome substitution (CSS) mice, to four candidate genes in silico. Expression levels of these candidate genes in prefrontal cortex, amygdala and nucleus accumbens, brain regions implicated in reward and addiction, were subsequently compared for the CSS-2 and the C57BL/6J host strain. RESULTS: We observed increased expression of adenosine deaminase-like (Adal) in all three regions in CSS-2 mice. Moreover, we found that the adenosine deaminase inhibitor EHNA reduced the difference in alcohol preference between CSS-2 and C57Bl/6J mice. CONCLUSION: The current study identifies Adal as a genetically protective factor against alcohol consumption in mice, in which elevated Adal levels contribute to low alcohol preference. This article is protected by copyright. All rights reserved.
Item Type: |
Article
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Additional Information: |
This is the peer reviewed version of the following article: Lesscher, H. M. B., Bailey, A. and Vanderschuren, L. J. M. J. (2017), Genetic Variability in Adenosine Deaminase-Like Contributes to Variation in Alcohol Preference in Mice. Alcohol Clin Exp Res, 41: 1271–1279, which has been published in final form at http://doi.org/10.1111/acer.13409. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: |
QTL, adenosine, alcohol, mice, preference, Substance Abuse, 1103 Clinical Sciences, 1701 Psychology, 1109 Neurosciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Institute of Medical & Biomedical Education (IMBE) Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE) |
Journal or Publication Title: |
Alcohol Clin Exp Res |
ISSN: |
1530-0277 |
Language: |
eng |
Dates: |
Date | Event |
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3 July 2017 | Published | 27 April 2017 | Published Online | 20 April 2017 | Accepted |
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Publisher License: |
Publisher's own licence |
Projects: |
Project ID | Funder | Funder ID |
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H06.08 | Brain Foundation of the Netherlands | UNSPECIFIED |
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PubMed ID: |
28449374 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/108817 |
Publisher's version: |
https://doi.org/10.1111/acer.13409 |
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