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Adlard, J;
Aittomäki, K;
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Arason, A;
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(2017)
Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3.
Breast Cancer Res Treat, 161 (1).
pp. 117-134.
ISSN 1573-7217
https://doi.org/10.1007/s10549-016-4018-2
SGUL Authors: Snape, Katie Mairwen Greenwood
Abstract
PURPOSE: Cis-acting regulatory SNPs resulting in differential allelic expression (DAE) may, in part, explain the underlying phenotypic variation associated with many complex diseases. To investigate whether common variants associated with DAE were involved in breast cancer susceptibility among BRCA1 and BRCA2 mutation carriers, a list of 175 genes was developed based of their involvement in cancer-related pathways. METHODS: Using data from a genome-wide map of SNPs associated with allelic expression, we assessed the association of ~320 SNPs located in the vicinity of these genes with breast and ovarian cancer risks in 15,252 BRCA1 and 8211 BRCA2 mutation carriers ascertained from 54 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2. RESULTS: We identified a region on 11q22.3 that is significantly associated with breast cancer risk in BRCA1 mutation carriers (most significant SNP rs228595 p = 7 × 10(-6)). This association was absent in BRCA2 carriers (p = 0.57). The 11q22.3 region notably encompasses genes such as ACAT1, NPAT, and ATM. Expression quantitative trait loci associations were observed in both normal breast and tumors across this region, namely for ACAT1, ATM, and other genes. In silico analysis revealed some overlap between top risk-associated SNPs and relevant biological features in mammary cell data, which suggests potential functional significance. CONCLUSION: We identified 11q22.3 as a new modifier locus in BRCA1 carriers. Replication in larger studies using estrogen receptor (ER)-negative or triple-negative (i.e., ER-, progesterone receptor-, and HER2-negative) cases could therefore be helpful to confirm the association of this locus with breast cancer risk.
Item Type: |
Article
|
Additional Information: |
This article is distributed under the terms of the
Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
Keywords: |
BRCA1 and BRCA2 mutation carriers, Breast cancer, Cis-regulatory variants, Differential allelic expression, Genetic modifiers, Genetic susceptibility, Oncology & Carcinogenesis, 1112 Oncology And Carcinogenesis |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS) |
Journal or Publication Title: |
Breast Cancer Res Treat |
ISSN: |
1573-7217 |
Language: |
eng |
Dates: |
Date | Event |
---|
1 January 2017 | Published | 28 October 2016 | Published Online | 8 October 2016 | Accepted |
|
Projects: |
Project ID | Funder | Funder ID |
---|
U10 CA180868 | NCI NIH HHS | UNSPECIFIED | R01 CA140323 | NCI NIH HHS | UNSPECIFIED | R01 CA176785 | NCI NIH HHS | UNSPECIFIED | RC4 CA153828 | NCI NIH HHS | UNSPECIFIED | R01 CA142996 | NCI NIH HHS | UNSPECIFIED | P50 CA125183 | NCI NIH HHS | UNSPECIFIED | UM1 CA164920 | NCI NIH HHS | UNSPECIFIED | P30 CA168524 | NCI NIH HHS | UNSPECIFIED | U01 CA161032 | NCI NIH HHS | UNSPECIFIED | U10 CA027469 | NCI NIH HHS | UNSPECIFIED | UL1 TR000124 | NCATS NIH HHS | UNSPECIFIED | U01 CA116167 | NCI NIH HHS | UNSPECIFIED | R01 CA128978 | NCI NIH HHS | UNSPECIFIED | R01 CA083855 | NCI NIH HHS | UNSPECIFIED | U19 CA148537 | NCI NIH HHS | UNSPECIFIED | P30 CA051008 | NCI NIH HHS | UNSPECIFIED | R01 CA116167 | NCI NIH HHS | UNSPECIFIED | P50 CA116201 | NCI NIH HHS | UNSPECIFIED | U01 CA113916 | NCI NIH HHS | UNSPECIFIED | U10 CA037517 | NCI NIH HHS | UNSPECIFIED | N02CP65504 | NCI NIH HHS | UNSPECIFIED | R01 CA102776 | NCI NIH HHS | UNSPECIFIED | U19 CA148112 | NCI NIH HHS | UNSPECIFIED | R01 CA149429 | NCI NIH HHS | UNSPECIFIED | U19 CA148065 | NCI NIH HHS | UNSPECIFIED | R01 CA192393 | NCI NIH HHS | UNSPECIFIED | U10 CA180822 | NCI NIH HHS | UNSPECIFIED | N02CP11019 | NCI NIH HHS | UNSPECIFIED |
|
PubMed ID: |
27796716 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/108605 |
Publisher's version: |
https://doi.org/10.1007/s10549-016-4018-2 |
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