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The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results.

Schotten, U; Hatem, S; Ravens, U; Jaïs, P; Müller, F-U; Goette, A; Rohr, S; Antoons, G; Pieske, B; Scherr, D; et al. Schotten, U; Hatem, S; Ravens, U; Jaïs, P; Müller, F-U; Goette, A; Rohr, S; Antoons, G; Pieske, B; Scherr, D; Oto, A; Casadei, B; Verheule, S; Cartlidge, D; Steinmeyer, K; Götsche, T; Dobrev, D; Kockskämper, J; Lendeckel, U; Fabritz, L; Kirchhof, P; Camm, AJ; EUTRAF investigators (2015) The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results. Europace, 17 (10). pp. 1457-1466. ISSN 1532-2092 https://doi.org/10.1093/europace/euv252
SGUL Authors: Camm, Alan John

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Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia in the general population. As an age-related arrhythmia AF is becoming a huge socio-economic burden for European healthcare systems. Despite significant progress in our understanding of the pathophysiology of AF, therapeutic strategies for AF have not changed substantially and the major challenges in the management of AF are still unmet. This lack of progress may be related to the multifactorial pathogenesis of atrial remodelling and AF that hampers the identification of causative pathophysiological alterations in individual patients. Also, again new mechanisms have been identified and the relative contribution of these mechanisms still has to be established. In November 2010, the European Union launched the large collaborative project EUTRAF (European Network of Translational Research in Atrial Fibrillation) to address these challenges. The main aims of EUTRAF are to study the main mechanisms of initiation and perpetuation of AF, to identify the molecular alterations underlying atrial remodelling, to develop markers allowing to monitor this processes, and suggest strategies to treat AF based on insights in newly defined disease mechanisms. This article reports on the objectives, the structure, and initial results of this network.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Europace following peer review. The version of record Ulrich Schotten, Stephane Hatem, Ursula Ravens, Pierre Jaïs, Frank-Ulrich Müller, Andres Goette, Stephan Rohr, Gudrun Antoons, Burkert Pieske, Daniel Scherr, Ali Oto, Barbara Casadei, Sander Verheule, David Cartlidge, Klaus Steinmeyer, Thorsten Götsche, Dobromir Dobrev, Jens Kockskämper, Uwe Lendeckel, Larissa Fabritz, Paulus Kirchhof, A. John Camm, on behalf of the EUTRAF investigators, The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results, EP Europace, Volume 17, Issue 10, October 2015, Pages 1457–1466 is available online at: https://doi.org/10.1093/europace/euv252
Keywords: Atrial fibrillation, Atrial remodelling, Biomarker, Diagnostic tools, Pathophysiology, Stroke, Atrial Fibrillation, Atrial Remodeling, Cooperative Behavior, Electrocardiography, Europe, Humans, Translational Medical Research, EUTRAF investigators, Humans, Atrial Fibrillation, Electrocardiography, Cooperative Behavior, Europe, Translational Medical Research, Atrial Remodeling, Atrial fibrillation, Pathophysiology, Atrial remodelling, Stroke, Biomarker, Diagnostic tools, Cardiovascular System & Hematology, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Europace
ISSN: 1532-2092
Language: eng
Dates:
DateEvent
October 2015Published
12 September 2015Published Online
29 June 2015Accepted
Publisher License: Publisher's own licence
PubMed ID: 26364316
Web of Science ID: WOS:000366488600001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/108508
Publisher's version: https://doi.org/10.1093/europace/euv252

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