Hainsworth, AH;
Allan, SM;
Boltze, J;
Cunningham, C;
Farris, C;
Head, E;
Ihara, M;
Isaacs, JD;
Kalaria, RN;
Lesnik Oberstein, SAMJ;
et al.
Hainsworth, AH; Allan, SM; Boltze, J; Cunningham, C; Farris, C; Head, E; Ihara, M; Isaacs, JD; Kalaria, RN; Lesnik Oberstein, SAMJ; Moss, MB; Nitzsche, B; Rosenberg, GA; Rutten, JW; Salkovic-Petrisic, M; Troen, AM
(2017)
Translational models for vascular cognitive impairment: a review including larger species.
BMC Med, 15 (1).
p. 16.
ISSN 1741-7015
https://doi.org/10.1186/s12916-017-0793-9
SGUL Authors: Hainsworth, Atticus Henry
Abstract
BACKGROUND: Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners. Synopses were refined by the authors, and subsequently by the scientific committee of a recent conference (International Conference on Vascular Dementia 2015). Only peer-reviewed sources were cited. METHODS: We included models that mimic VCI-related brain lesions (white matter hypoperfusion injury, focal ischaemia, cerebral amyloid angiopathy) or reproduce VCI risk factors (old age, hypertension, hyperhomocysteinemia, high-salt/high-fat diet) or reproduce genetic causes of VCI (CADASIL-causing Notch3 mutations). CONCLUSIONS: We concluded that (1) translational models may reflect a VCI-relevant pathological process, while not fully replicating a human disease spectrum; (2) rodent models of VCI are limited by paucity of white matter; and (3) further translational models, and improved cognitive testing instruments, are required.
Item Type: |
Article
|
Additional Information: |
© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Keywords: |
Experimental models, In vivo models, Translational models, VCID, Vascular cognitive impairment, Vascular dementia, General & Internal Medicine, 11 Medical And Health Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
BMC Med |
ISSN: |
1741-7015 |
Language: |
eng |
Dates: |
Date | Event |
---|
25 January 2017 | Published | 12 January 2017 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
Project ID | Funder | Funder ID |
---|
20140901 | Alzheimer's Drug Discovery Foundation | UNSPECIFIED | PG146/151 | Alzheimer's Society | UNSPECIFIED | PPG2014A-8 | Alzheimer's Research UK | UNSPECIFIED |
|
PubMed ID: |
28118831 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/108504 |
Publisher's version: |
https://doi.org/10.1186/s12916-017-0793-9 |
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