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Disruption of rich club organisation in cerebral small vessel disease.

Tuladhar, AM; Lawrence, A; Norris, DG; Barrick, TR; Markus, HS; de Leeuw, F-E (2017) Disruption of rich club organisation in cerebral small vessel disease. Hum Brain Mapp, 38 (4). pp. 1751-1766. ISSN 1097-0193 https://doi.org/10.1002/hbm.23479
SGUL Authors: Barrick, Thomas Richard

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Abstract

Cerebral small vessel disease (SVD) is an important cause of vascular cognitive impairment. Recent studies have demonstrated that structural connectivity of brain networks in SVD is disrupted. However, little is known about the extent and location of the reduced connectivity in SVD. Here they investigate the rich club organisation-a set of highly connected and interconnected regions-and investigate whether there is preferential rich club disruption in SVD. Diffusion tensor imaging (DTI) and cognitive assessment were performed in a discovery sample of SVD patients (n = 115) and healthy control subjects (n = 50). Results were replicated in an independent dataset (49 SVD with confluent WMH cases and 108 SVD controls) with SVD patients having a similar SVD phenotype to that of the discovery cases. Rich club organisation was examined in structural networks derived from DTI followed by deterministic tractography. Structural networks in SVD patients were less dense with lower network strength and efficiency. Reduced connectivity was found in SVD, which was preferentially located in the connectivity between the rich club nodes rather than in the feeder and peripheral connections, a finding confirmed in both datasets. In discovery dataset, lower rich club connectivity was associated with lower scores on psychomotor speed (β = 0.29, P < 0.001) and executive functions (β = 0.20, P = 0.009). These results suggest that SVD is characterized by abnormal connectivity between rich club hubs in SVD and provide evidence that abnormal rich club organisation might contribute to the development of cognitive impairment in SVD.

Item Type: Article
Additional Information: © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: cerebral small vessel disease, diffusion tensor imaging, graph-theory, rich club organisation, structural networks, Experimental Psychology, 1109 Neurosciences, 1702 Cognitive Science
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Neuroscience (INCCNS)
Journal or Publication Title: Hum Brain Mapp
ISSN: 1097-0193
Language: eng
Dates:
DateEvent
9 December 2016Published Online
16 November 2016Accepted
April 2017Published
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
ARUK-EXT2013-2Alzheimer’s Research UKhttp://dx.doi.org/10.13039/501100002283
081589Wellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 27935154
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/108476
Publisher's version: https://doi.org/10.1002/hbm.23479

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