Lynch, M; Barallobre-Barreiro, J; Jahangiri, M; Mayr, M
(2016)
Vascular proteomics in metabolic and cardiovascular diseases.
J Intern Med, 280 (4).
pp. 325-338.
ISSN 1365-2796
https://doi.org/10.1111/joim.12486
SGUL Authors: Jahangiri, Marjan
Abstract
The vasculature is essential for proper organ function. Many pathologies are directly and indirectly related to vascular dysfunction, which causes significant morbidity and mortality. A common pathophysiological feature of diseased vessels is extracellular matrix (ECM) remodelling. Analysing the protein composition of the ECM by conventional antibody-based techniques is challenging; alternative splicing or post-translational modifications, such as glycosylation, can mask epitopes required for antibody recognition. By contrast, proteomic analysis by mass spectrometry enables the study of proteins without the constraints of antibodies. Recent advances in proteomic techniques make it feasible to characterize the composition of the vascular ECM and its remodelling in disease. These developments may lead to the discovery of novel prognostic and diagnostic markers. Thus, proteomics holds potential for identifying ECM signatures to monitor vascular disease processes. Furthermore, a better understanding of the ECM remodelling processes in the vasculature might make ECM-associated proteins more attractive targets for drug discovery efforts. In this review, we will summarize the role of the ECM in the vasculature. Then, we will describe the challenges associated with studying the intricate network of ECM proteins and the current proteomic strategies to analyse the vascular ECM in metabolic and cardiovascular diseases.
Item Type: |
Article
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Additional Information: |
© 2016 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: |
apolipoproteins, atherosclerosis, diabetes, proteomics, restenosis, vascular biology, apolipoproteins, atherosclerosis, diabetes, proteomics, restenosis, vascular biology, Cardiovascular System & Hematology, 1103 Clinical Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA) |
Journal or Publication Title: |
J Intern Med |
ISSN: |
1365-2796 |
Language: |
eng |
Dates: |
Date | Event |
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October 2016 | Published | 4 March 2016 | Published Online |
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Projects: |
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PubMed ID: |
26940365 |
Web of Science ID: |
WOS:000386917000001 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/108470 |
Publisher's version: |
https://doi.org/10.1111/joim.12486 |
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