Figueiredo, CA; Amorim, LD; Vaca, M; Chico, ME; Campos, AC; Barreto, ML; Cooper, PJ
(2016)
Effects of poor hygiene on cytokine phenotypes in children in the tropics.
World Allergy Organization Journal, 9 (1).
p. 34.
ISSN 1939-4551
https://doi.org/10.1186/s40413-016-0124-1
SGUL Authors: Cooper, Philip John
Abstract
We describe immune phenotypes (innate and adaptive cytokines) according to environmental exposure using latent class analysis. A total of 310 schoolchildren living in Ecuador were assayed for spontaneous cytokine production as well as mitogen (SEB)-stimulated cytokines in whole blood cultures. We collected data on environmental exposures by questionnaire and on intestinal parasites by examination of stool samples. Latent class analysis (LCA) was used to group children according to their innate (IL-6, IL-8, IL-10 and TNF-α) and adaptive (IL-5, IL-13, IL-17, IFN-γ and IL-10) cytokine profile. We also conducted multiple-group LCA and LCA with covariates to evaluate the effect of predictors on profile membership. We identified both hyporesponsive and Th2-modified immune phenotypes produced by peripheral blood leukocytes (PBLs) that were associated with intestinal worms and birth order, providing insights into how poor hygiene mediates immunologic effects on immune-mediated diseases.
Item Type: |
Article
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Additional Information: |
© 2016 Figueiredo et al.
Open Access
This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Keywords: |
Cytokines, Environment, Hygiene, Latent class analysis, Latin America, Tropics, Cytokines, Environment, Hygiene, Latent class analysis, Latin America, Tropics, 1103 Clinical Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
World Allergy Organization Journal |
ISSN: |
1939-4551 |
Language: |
ENG |
Dates: |
Date | Event |
---|
3 November 2016 | Published | 22 September 2016 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
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PubMed ID: |
27843530 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/108413 |
Publisher's version: |
https://doi.org/10.1186/s40413-016-0124-1 |
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