Alam, MH;
He, T;
Auger, D;
Smith, GC;
Drivas, P;
Wage, R;
Izgi, C;
Symmonds, K;
Greiser, A;
Spottiswoode, BS;
et al.
Alam, MH; He, T; Auger, D; Smith, GC; Drivas, P; Wage, R; Izgi, C; Symmonds, K; Greiser, A; Spottiswoode, BS; Anderson, L; Firmin, D; Pennell, DJ
(2016)
Validation of T2* in-line analysis for tissue iron quantification at 1.5 T.
Journal of Cardiovascular Magnetics Resonance, 18 (1).
p. 23.
ISSN 1532-429X
https://doi.org/10.1186/s12968-016-0243-4
SGUL Authors: He, Taigang
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Abstract
BACKGROUND: There is a need for improved worldwide access to tissue iron quantification using T2* cardiovascular magnetic resonance (CMR). One route to facilitate this would be simple in-line T2* analysis widely available on MR scanners. We therefore compared our clinically validated and established T2* method at Royal Brompton Hospital (RBH T2*) against a novel work-in-progress (WIP) sequence with in-line T2* measurement from Siemens (WIP T2*). METHODS: Healthy volunteers (n = 22) and patients with iron overload (n = 78) were recruited (53 males, median age 34 years). A 1.5 T study (Magnetom Avanto, Siemens) was performed on all subjects. The same mid-ventricular short axis cardiac slice and transaxial slice through the liver were used to acquire both RBH T2* images and WIP T2* maps for each participant. Cardiac white blood (WB) and black blood (BB) sequences were acquired. Intraobserver, interobserver and interstudy reproducibility were measured on the same data from a subset of 20 participants. RESULTS: Liver T2* values ranged from 0.8 to 35.7 ms (median 5.1 ms) and cardiac T2* values from 6.0 to 52.3 ms (median 31 ms). The coefficient of variance (CoV) values for direct comparison of T2* values by RBH and WIP were 6.1-7.8 % across techniques. Accurate delineation of the septum was difficult on some WIP T2* maps due to artefacts. The inability to manually correct for noise by truncation of erroneous later echo times led to some overestimation of T2* using WIP T2* compared with the RBH T2*. Reproducibility CoV results for RBH T2* ranged from 1.5 to 5.7 % which were better than the reproducibility of WIP T2* values of 4.1-16.6 %. CONCLUSIONS: Iron estimation using the T2* CMR sequence in combination with Siemens' in-line data processing is generally satisfactory and may help facilitate global access to tissue iron assessment. The current automated T2* map technique is less good for tissue iron assessment with noisy data at low T2* values.
Item Type: | Article | ||||||
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Additional Information: | © 2016 Alam et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | ||||||
Keywords: | CMR, Heart, In-line processing, Iron overload, Liver, T2*, CMR, T2*, In-line processing, Heart, Liver, Iron overload, CMR, Heart, In-line processing, Iron overload, Liver, T2*, Nuclear Medicine & Medical Imaging, 1102 Cardiovascular Medicine And Haematology | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA) |
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Journal or Publication Title: | Journal of Cardiovascular Magnetics Resonance | ||||||
ISSN: | 1532-429X | ||||||
Language: | ENG | ||||||
Publisher License: | Creative Commons: Attribution 4.0 | ||||||
Projects: |
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PubMed ID: | 27121114 | ||||||
Web of Science ID: | WOS:000374865900001 | ||||||
Go to PubMed abstract | |||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/108336 | ||||||
Publisher's version: | https://doi.org/10.1186/s12968-016-0243-4 |
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