Alam, MH;
Auger, D;
McGill, L-A;
Smith, GC;
He, T;
Izgi, C;
Baksi, AJ;
Wage, R;
Drivas, P;
Firmin, DN;
et al.
Alam, MH; Auger, D; McGill, L-A; Smith, GC; He, T; Izgi, C; Baksi, AJ; Wage, R; Drivas, P; Firmin, DN; Pennell, DJ
(2016)
Comparison of 3 T and 1.5 T for T2* magnetic resonance of tissue iron.
Journal of Cardiovascular Magnetic Resonance, 18 (1).
p. 40.
ISSN 1532-429X
https://doi.org/10.1186/s12968-016-0259-9
SGUL Authors: He, Taigang
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Abstract
BACKGROUND: T2* magnetic resonance of tissue iron concentration has improved the outcome of transfusion dependant anaemia patients. Clinical evaluation is performed at 1.5 T but scanners operating at 3 T are increasing in numbers. There is a paucity of data on the relative merits of iron quantification at 3 T vs 1.5 T. METHODS: A total of 104 transfusion dependent anaemia patients and 20 normal volunteers were prospectively recruited to undergo cardiac and liver T2* assessment at both 1.5 T and 3 T. Intra-observer, inter-observer and inter-study reproducibility analysis were performed on 20 randomly selected patients for cardiac and liver T2*. RESULTS: Association between heart and liver T2* at 1.5 T and 3 T was non-linear with good fit (R (2) = 0.954, p < 0.001 for heart white-blood (WB) imaging; R (2) = 0.931, p < 0.001 for heart black-blood (BB) imaging; R (2) = 0.993, p < 0.001 for liver imaging). R2* approximately doubled between 1.5 T and 3 T with linear fits for both heart and liver (94, 94 and 105 % respectively). Coefficients of variation for intra- and inter-observer reproducibility, as well as inter-study reproducibility trended to be less good at 3 T (3.5 to 6.5 %) than at 1.5 T (1.4 to 5.7 %) for both heart and liver T2*. Artefact scores for the heart were significantly worse with the 3 T BB sequence (median 4, IQR 2-5) compared with the 1.5 T BB sequence (4 [3-5], p = 0.007). CONCLUSION: Heart and liver T2* and R2* at 3 T show close association with 1.5 T values, but there were more artefacts at 3 T and trends to lower reproducibility causing difficulty in quantifying low T2* values with high tissue iron. Therefore T2* imaging at 1.5 T remains the gold standard for clinical practice. However, in centres where only 3 T is available, equivalent values at 1.5 T may be approximated by halving the 3 T tissue R2* with subsequent conversion to T2*.
Item Type: | Article | ||||||
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Additional Information: | © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | ||||||
Keywords: | 3 T, Heart, Iron overload, Liver, Magnetic resonance, Siderosis, T2*, Magnetic resonance, 3 T, Heart, Liver, Iron overload, Siderosis, T2*, 3 T, Heart, Iron overload, Liver, Magnetic resonance, Siderosis, T2*, Nuclear Medicine & Medical Imaging, 1102 Cardiovascular Medicine And Haematology | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA) |
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Journal or Publication Title: | Journal of Cardiovascular Magnetic Resonance | ||||||
ISSN: | 1532-429X | ||||||
Language: | ENG | ||||||
Publisher License: | Creative Commons: Attribution-No Derivative Works 4.0 | ||||||
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PubMed ID: | 27391316 | ||||||
Web of Science ID: | WOS:000379550300001 | ||||||
Go to PubMed abstract | |||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/108331 | ||||||
Publisher's version: | https://doi.org/10.1186/s12968-016-0259-9 |
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