D'Antonio, F; Familiari, A; Thilaganathan, B; Papageorghiou, AT; Manzoli, L; Khalil, A; Bhide, A
(2016)
Sensitivity of first trimester ultrasound in the detection of congenital anomalies in twin pregnancies: population study and systematic review.
Acta Obstetricia et Gynecologica Scandinavica, 95 (12).
pp. 1359-1367.
ISSN 1600-0412
https://doi.org/10.1111/aogs.13017
SGUL Authors: Thilaganathan, Baskaran Bhide, Amarnath Khalil, Asma Bhide, Amarnath
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Abstract
INTRODUCTION: The first aim of this study was to ascertain the diagnostic performance of first trimester ultrasound in detecting congenital anomalies in twins. The secondary aim was to explore the strength of association between different pregnancy characteristics and early detection of structural anomalies in a large unselected population of twin pregnancies. A systematic review of the published literature was also carried out MATERIAL AND METHODS: Retrospective analysis of prospectively collected data from consecutive twin pregnancies booked for antenatal care from 1996 till 2014. Predictive accuracy of those covariates independently associated with the occurrence of fetal anomalies were assessed with logistic regression analysis and ROC curves RESULTS: 1064 twin pregnancies (820 dichorionic and 264 monochorionic) were included in the analysis. 42 pregnancies had one or more fetuses with structural abnormalities. Detection of structural abnormalities using ultrasound was possible in the first trimester in 27.3% (95% CI: 15.0-42.8) of twin pregnancies. Mono-chorionicity (OR 2.3, 95% CI: 1.1-4.7) and discordance in crown-rump length and nuchal translucency were associated with an increased risk of fetal anomalies. However, their predictive accuracy was only moderate (AUC: 0.67, 95% CI: 0.6-0.8 and 0.68, 95% CI: 0.6 - 0.8, for crown-rump length and nuchal translucency discrepancy respectively CONCLUSIONS: First trimester detection of structural abnormalities in twin pregnancies is possible in 27.3% (95% CI: 15.0-42.8) of cases. The likelihood for first trimester detection of structural anomalies in twins was maximum for cranial vault, midline brain and abdominal wall defects. Monochorionicity and increasing discrepancy in crown-rump length and nuchal translucency were associated with fetal structural abnormalities, although their predictive performance was only moderately good. This article is protected by copyright. All rights reserved.
Item Type: | Article | ||||||||
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Additional Information: | This is the peer reviewed version of the following article: D'Antonio, F., Familiari, A., Thilaganathan, B., Papageorghiou, A. T., Manzoli, L., Khalil, A. and Bhide, A. (2016), Sensitivity of first trimester ultrasound in the detection of congenital anomalies in twin pregnancies: population study and systematic review. Acta Obstet Gynecol Scand 2016; 95:1359–1367. Accepted Author Manuscript, which has been published in final form at http://dx.doi.org/10.1111/aogs.13017. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | ||||||||
Keywords: | Prenatal diagnosis, congenital anomalies, first trimester, multiple gestations, ultrasound, Prenatal diagnosis, congenital anomalies, first trimester, multiple gestations, ultrasound, Obstetrics & Reproductive Medicine, 1114 Paediatrics And Reproductive Medicine, 1117 Public Health And Health Services | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Institute of Medical & Biomedical Education (IMBE) Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE ) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Vascular (INCCVA) |
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Journal or Publication Title: | Acta Obstetricia et Gynecologica Scandinavica | ||||||||
ISSN: | 1600-0412 | ||||||||
Language: | ENG | ||||||||
Dates: |
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Publisher License: | Publisher's own licence | ||||||||
PubMed ID: | 27622859 | ||||||||
Go to PubMed abstract | |||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/108269 | ||||||||
Publisher's version: | https://doi.org/10.1111/aogs.13017 |
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