Möller, T;
Bard, F;
Bhattacharya, A;
Biber, K;
Campbell, B;
Dale, E;
Eder, C;
Gan, L;
Garden, GA;
Hughes, ZA;
et al.
Möller, T; Bard, F; Bhattacharya, A; Biber, K; Campbell, B; Dale, E; Eder, C; Gan, L; Garden, GA; Hughes, ZA; Pearse, DD; Staal, RGW; Sayed, FA; Wes, PD; Boddeke, HWGM
(2016)
Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
Glia, 64 (10).
pp. 1788-1794.
ISSN 1098-1136
https://doi.org/10.1002/glia.23007
SGUL Authors: Eder, Claudia
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Abstract
Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to "inhibition" of microglia. It is, however, unclear how this "inhibition" is achieved at the molecular and cellular levels. Here, we weigh the evidence whether minocycline is indeed a bona fide microglia inhibitor and discuss how data generated with minocycline should be interpreted. GLIA 2016;64:1788-1794.
| Item Type: | Article | ||||||||
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| Additional Information: | This is the peer reviewed version of the following article: Möller, T., Bard, F., Bhattacharya, A., Biber, K., Campbell, B., Dale, E., Eder, C., Gan, L., Garden, G. A., Hughes, Z. A., Pearse, D. D., Staal, R. G. W., Sayed, F. A., Wes, P. D. and Boddeke, H. W. G. M. (2016), Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor. Glia, 64: 1788–1794, which has been published in final form at http://dx.doi.org/10.1002/glia.23007. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | ||||||||
| Keywords: | inhibitor, lack of specificity, microglia, minocycline, inhibitor, lack of specificity, microglia, minocycline, Neurology & Neurosurgery, 1109 Neurosciences | ||||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | ||||||||
| Journal or Publication Title: | Glia | ||||||||
| ISSN: | 1098-1136 | ||||||||
| Language: | eng | ||||||||
| Dates: |
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| Publisher License: | Publisher's own licence | ||||||||
| PubMed ID: | 27246804 | ||||||||
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Go to PubMed abstract | ||||||||
| URI: | https://openaccess.sgul.ac.uk/id/eprint/108202 | ||||||||
| Publisher's version: | https://doi.org/10.1002/glia.23007 |
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