Dale, E; Staal, RGW; Eder, C; Möller, T
(2016)
KCa 3.1-a microglial target ready for drug repurposing?
Glia, 64 (10).
pp. 1733-1741.
ISSN 1098-1136
https://doi.org/10.1002/glia.22992
SGUL Authors: Eder, Claudia
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Abstract
Over the past decade, glial cells have attracted attention for harboring unexploited targets for drug discovery. Several glial targets have attracted de novo drug discovery programs, as highlighted in this GLIA Special Issue. Drug repurposing, which has the objective of utilizing existing drugs as well as abandoned, failed, or not yet pursued clinical development candidates for new indications, might provide a faster opportunity to bring drugs for glial targets to patients with unmet needs. Here, we review the potential of the intermediate-conductance calcium-activated potassium channels KCa 3.1 as the target for such a repurposing effort. We discuss the data on KCa 3.1 expression on microglia in vitro and in vivo and review the relevant literature on the two KCa 3.1 inhibitors TRAM-34 and Senicapoc. Finally, we provide an outlook of what it might take to harness the potential of KCa 3.1 as a bona fide microglial drug target. GLIA 2016;64:1733-1741.
Item Type: |
Article
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Additional Information: |
This is the peer reviewed version of the following article: Dale, E., Staal, R. G. W., Eder, C. and Möller, T. (2016), KCa3.1—a microglial target ready for drug repurposing?. Glia, 64: 1733–1741, which has been published in final form at http://dx.doi.org/10.1002/glia.22992. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving |
Keywords: |
KCa3.1, NCATS, drug repurposing, drug target, microglia, KCa3.1, NCATS, drug repurposing, drug target, microglia, Neurology & Neurosurgery, 1109 Neurosciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Glia |
ISSN: |
1098-1136 |
Language: |
eng |
Dates: |
Date | Event |
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1 October 2016 | Published | 28 April 2016 | Published Online | 3 April 2016 | Accepted |
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Publisher License: |
Publisher's own licence |
PubMed ID: |
27121595 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/108201 |
Publisher's version: |
https://doi.org/10.1002/glia.22992 |
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