Golding, JP; Goatley, L; Goodbourn, S; Dixon, LK; Taylor, G; Netherton, CL
(2016)
Sensitivity of African swine fever virus to type I interferon is linked to genes within multigene families 360 and 505.
Virology, 493.
pp. 154-161.
ISSN 1096-0341
https://doi.org/10.1016/j.virol.2016.03.019
SGUL Authors: Goodbourn, Stephen Edward
Abstract
African swine fever virus (ASFV) causes a lethal haemorrhagic disease of pigs. There are conflicting reports on the role of interferon in ASFV infection. We therefore analysed the interaction of ASFV with porcine interferon, in vivo and in vitro. Virulent ASFV induced biologically active IFN in the circulation of pigs from day 3-post infection, whereas low virulent OUR T88/3, which lacks genes from multigene family (MGF) 360 and MGF505, did not. Infection of porcine leucocytes enriched for dendritic cells, with ASFV, in vitro, induced high levels of interferon, suggesting a potential source of interferon in animals undergoing acute ASF. Replication of OUR T88/3, but not virulent viruses, was reduced in interferon pretreated macrophages and a recombinant virus lacking similar genes to those absent in OUR T88/3 was also inhibited. These findings suggest that as well as inhibiting the induction of interferon, MGF360 and MGF505 genes also enable ASFV to overcome the antiviral state.
Item Type: |
Article
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Additional Information: |
© 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: |
African swine fever virus, Asfarviridae, Cytokine, Dendritic cell, Immune evasion, Innate immunity, Interferon, Macrophage, Multigene family, Pig, African swine fever virus, Interferon, Multigene family, Pig, Cytokine, Innate immunity, Immune evasion, Asfarviridae, Macrophage, Dendritic cell, African swine fever virus, Asfarviridae, Cytokine, Dendritic cell, Immune evasion, Innate immunity, Interferon, Macrophage, Multigene family, Pig, Virology, 06 Biological Sciences, 11 Medical And Health Sciences, 07 Agricultural And Veterinary Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Virology |
ISSN: |
1096-0341 |
Language: |
eng |
Dates: |
Date | Event |
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1 June 2016 | Published | 1 April 2016 | Published Online | 24 March 2016 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
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PubMed ID: |
27043071 |
Web of Science ID: |
WOS:000375824300015 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/108166 |
Publisher's version: |
https://doi.org/10.1016/j.virol.2016.03.019 |
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