Cheng, THT;
Thompson, DJ;
O'Mara, TA;
Painter, JN;
Glubb, DM;
Flach, S;
Lewis, A;
French, JD;
Freeman-Mills, L;
Church, D;
et al.
Cheng, THT; Thompson, DJ; O'Mara, TA; Painter, JN; Glubb, DM; Flach, S; Lewis, A; French, JD; Freeman-Mills, L; Church, D; Gorman, M; Martin, L; National Study of Endometrial Cancer Genetics Group (NSECG); Hodgson, S; Webb, PM; Australian National Endometrial Cancer Study Group (ANECS); Attia, J; Holliday, EG; McEvoy, M; Scott, RJ; Henders, AK; Martin, NG; Montgomery, GW; Nyholt, DR; Ahmed, S; Healey, CS; Shah, M; Dennis, J; Fasching, PA; Beckmann, MW; Hein, A; Ekici, AB; Hall, P; Czene, K; Darabi, H; Li, J; Dörk, T; Dürst, M; Hillemanns, P; Runnebaum, I; Amant, F; Schrauwen, S; Zhao, H; Lambrechts, D; Depreeuw, J; Dowdy, SC; Goode, EL; Fridley, BL; Winham, SJ; Njølstad, TS; Salvesen, HB; Trovik, J; Werner, HMJ; Ashton, K; Otton, G; Proietto, T; Liu, T; Mints, M; Tham, E; RENDOCAS; CHIBCHA Consortium; Li, MJ; Yip, SH; Wang, J; Bolla, MK; Michailidou, K; Wang, Q; Tyrer, JP; Dunlop, M; Houlston, R; Palles, C; Hopper, JL; AOCS Group; Peto, J; Swerdlow, AJ; Burwinkel, B; Brenner, H; Meindl, A; Brauch, H; Lindblom, A; Chang-Claude, J; Couch, FJ; Giles, GG; Kristensen, VN; Cox, A; Cunningham, JM; Pharoah, PDP; Dunning, AM; Edwards, SL; Easton, DF; Tomlinson, I; Spurdle, AB
(2016)
Five endometrial cancer risk loci identified through genome-wide association analysis.
Nature Genetics, 48 (6).
pp. 667-674.
https://doi.org/10.1038/ng.3562
SGUL Authors: Hodgson, Shirley Victoria
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Abstract
We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and 37,144 controls of European ancestry. Genome-wide imputation and meta-analysis identified five new risk loci of genome-wide significance at likely regulatory regions on chromosomes 13q22.1 (rs11841589, near KLF5), 6q22.31 (rs13328298, in LOC643623 and near HEY2 and NCOA7), 8q24.21 (rs4733613, telomeric to MYC), 15q15.1 (rs937213, in EIF2AK4, near BMF) and 14q32.33 (rs2498796, in AKT1, near SIVA1). We also found a second independent 8q24.21 signal (rs17232730). Functional studies of the 13q22.1 locus showed that rs9600103 (pairwise r(2) = 0.98 with rs11841589) is located in a region of active chromatin that interacts with the KLF5 promoter region. The rs9600103[T] allele that is protective in endometrial cancer suppressed gene expression in vitro, suggesting that regulation of the expression of KLF5, a gene linked to uterine development, is implicated in tumorigenesis. These findings provide enhanced insight into the genetic and biological basis of endometrial cancer.
Item Type: | Article | ||||||||
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Additional Information: | Accepted manuscript made available for non commercial academic use only. Articles published by Nature Publishing Group (NPG) which are made available through academic repositories remain subject to copyright. Any reuse is subject to permission from NPG. | ||||||||
Keywords: | National Study of Endometrial Cancer Genetics Group (NSECG), Australian National Endometrial Cancer Study Group (ANECS), RENDOCAS, CHIBCHA Consortium, AOCS Group, Developmental Biology, 11 Medical And Health Sciences, 06 Biological Sciences | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS) |
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Journal or Publication Title: | Nature Genetics | ||||||||
Language: | eng | ||||||||
Dates: |
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Publisher License: | Publisher's own licence | ||||||||
PubMed ID: | 27135401 | ||||||||
Web of Science ID: | WOS:000376744200015 | ||||||||
Go to PubMed abstract | |||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/108148 | ||||||||
Publisher's version: | https://doi.org/10.1038/ng.3562 |
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