Baruteau, A-E; Pass, RH; Thambo, J-B; Behaghel, A; Le Pennec, S; Perdreau, E; Combes, N; Liberman, L; McLeod, CJ
(2016)
Congenital and childhood atrioventricular blocks: pathophysiology and contemporary management.
European Journal of Pediatrics, 175 (9).
pp. 1235-1248.
ISSN 0340-6199
https://doi.org/10.1007/s00431-016-2748-0
SGUL Authors: Baruteau, Alban-Elouen Ada
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Abstract
Atrioventricular block is classified as congeni- tal if diagnosed in utero, at birth, or within the first month of life. The pathophysiological process is believed to be due to immune-mediated injury of the conduction system, which occurs as a result of transplacental pas- sage of maternal anti-SSA/Ro-SSB/La antibodies. Childhood atrioventricular block is therefore diagnosed between the first month and the 18th year of life. Genetic variants in multiple genes have been described to date in the pathogenesis of inherited progressive car- diac conduction disorders. Indications and techniques of cardiac pacing have also evolved to allow safe perma- nent cardiac pacing in almost all patients, including those with structural heart abnormalities.
Item Type: | Article |
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Additional Information: | © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
Keywords: | Pediatrics, 1114 Paediatrics And Reproductive Medicine, 1117 Public Health And Health Services |
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: | European Journal of Pediatrics |
ISSN: | 0340-6199 |
Publisher License: | Creative Commons: Attribution 4.0 |
URI: | https://openaccess.sgul.ac.uk/id/eprint/108141 |
Publisher's version: | https://doi.org/10.1007/s00431-016-2748-0 |
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