Baruteau, A-E; Pass, RH; Thambo, J-B; Behaghel, A; Le Pennec, S; Perdreau, E; Combes, N; Liberman, L; McLeod, CJ
(2016)
Congenital and childhood atrioventricular blocks: pathophysiology and contemporary management.
European Journal of Pediatrics, 175 (9).
pp. 1235-1248.
ISSN 0340-6199
https://doi.org/10.1007/s00431-016-2748-0
SGUL Authors: Baruteau, Alban-Elouen Ada
Abstract
Atrioventricular block is classified as congeni-
tal if diagnosed in utero, at birth, or within the first
month of life. The pathophysiological process is believed
to be due to immune-mediated injury of the conduction
system, which occurs as a result of transplacental pas-
sage of maternal anti-SSA/Ro-SSB/La antibodies.
Childhood atrioventricular block is therefore diagnosed
between the first month and the 18th year of life.
Genetic variants in multiple genes have been described
to date in the pathogenesis of inherited progressive car-
diac conduction disorders. Indications and techniques of
cardiac pacing have also evolved to allow safe perma-
nent cardiac pacing in almost all patients, including
those with structural heart abnormalities.
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