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Region-specific up-regulation of oxytocin receptor binding in the brain of mice following chronic nicotine administration.

Zanos, P; Georgiou, P; Metaxas, A; Kitchen, I; Winsky-Sommerer, R; Bailey, A (2015) Region-specific up-regulation of oxytocin receptor binding in the brain of mice following chronic nicotine administration. Neuroscience Letters, 600. pp. 33-37. ISSN 1872-7972
SGUL Authors: Bailey, Alexis

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Nicotine addiction is considered to be the main preventable cause of death worldwide. While growing evidence indicates that the neurohypophysial peptide oxytocin can modulate the addictive properties of several abused drugs, the regulation of the oxytocinergic system following nicotine administration has so far received little attention. Here, we examined the effects of long-term nicotine or saline administration on the central oxytocinergic system using [(125)I]OVTA autoradiographic binding in mouse brain. Male, 7-week old C57BL6J mice were treated with either nicotine (7.8 mg/kg daily; rate of 0.5 μl per hour) or saline for a period of 14-days via osmotic minipumps. Chronic nicotine administration induced a marked region-specific upregulation of the oxytocin receptor binding in the amygdala, a brain region involved in stress and emotional regulation. These results provide direct evidence for nicotine-induced neuroadaptations in the oxytocinergic system, which may be involved in the modulation of nicotine-seeking as well as emotional consequence of chronic drug use.

Item Type: Article
Additional Information: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Keywords: Amygdala, Mice, Nicotine, Oxytocin receptor, Animals, Brain, Dose-Response Relationship, Drug, Male, Mice, Inbred C57BL, Nicotine, Organ Specificity, Receptors, Oxytocin, Tobacco Use Disorder, Brain, Animals, Mice, Inbred C57BL, Tobacco Use Disorder, Nicotine, Receptors, Oxytocin, Organ Specificity, Dose-Response Relationship, Drug, Male, Nicotine, Oxytocin receptor, Amygdala, Mice, 1109 Neurosciences, 1702 Cognitive Science, 1701 Psychology
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: Neuroscience Letters
ISSN: 1872-7972
Language: eng
23 July 2015Published
24 May 2015Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 26037668
Web of Science ID: WOS:000358627900007
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