Lindsay, J; Bal, AM; Coombs, GW; Holden, MTG; Nimmo, GR; Tattevin, P; Skov, RL
(2016)
Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin- resistant Staphylococcus aureus: Blurring of the traditional definitions.
Journal of Global Antimicrobial Resistance, 6.
pp. 95-101.
ISSN 2213-7165
https://doi.org/10.1016/j.jgar.2016.04.004
SGUL Authors: Lindsay, Jodi Anne
Abstract
The evolution of meticillin-resistant Staphylococcus aureus (MRSA) from meticillin-susceptible S. aureus has been a result of the accumulation of genetic elements under selection pressure from antibiotics. The traditional classification of MRSA into healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) is no longer relevant as there is significant overlap of identical clones between these groups, with an increasing recognition of human infection caused by livestock-associated MRSA (LA-MRSA). Genomic studies have enabled us to model the epidemiology of MRSA along these lines. In this review, we discuss the clinical relevance of genomic studies, particularly whole-genome sequencing, in the investigation of outbreaks. We also discuss the blurring of each of the three epidemiological groups (HA-MRSA, CA-MRSA and LA-MRSA), demonstrating the limited relevance of this classification.
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