Ahmed-Jushuf, F; Jiwa, NS; Arwani, AS; Foot, P; Bridges, LR; Kalaria, RN; Esiri, MM; Hainsworth, AH
(2016)
Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL, and healthy brains.
Neurobiology of Aging, 42.
pp. 110-115.
ISSN 0197-4580
https://doi.org/10.1016/j.neurobiolaging.2016.03.002
SGUL Authors: Hainsworth, Atticus Henry
Abstract
Vascular myocytes are central to brain aging. Small vessel disease (SVD; arteriolosclerosis)
is a widespread cause of lacunar stroke and vascular dementia, and is characterised by
fibrosis and depletion of vascular myocytes in small penetrating arteries. Vascular
endothelial growth factor (VEGF) is associated with brain aging, and VEGFR2 is a potent
determinant of cell fate. Here, we tested whether VEGFR2 in vascular myocytes is
associated with older age and SVD in human brain.
VEGFR2 immunolabelling in deep grey matter was assessed in older people with or without
moderate-severe SVD, or in younger people without brain pathology or with a monogenic
form of SVD (CADASIL). All cases were without Alzheimer’s disease pathology. Myocyte
VEGFR2 was associated with increasing age (p=0.0026) but not with SVD pathology or
with sclerotic index or blood vessel density. We conclude that VEGFR2 is consistently
expressed in small artery myocytes of older people, and may mediate effects of VEGF on
brain vascular aging.
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