Verkman, AS; Anderson, MO; Papadopoulos, MC
(2014)
Aquaporins: important but elusive drug targets.
Nat Rev Drug Discov, 13 (4).
pp. 259-277.
ISSN 1474-1784
https://doi.org/10.1038/nrd4226
SGUL Authors: Papadopoulos, Marios
![[img]](https://openaccess.sgul.ac.uk/107695/7.hassmallThumbnailVersion/nihms584852.pdf) ![](https://openaccess.sgul.ac.uk/107695/7.haspreviewThumbnailVersion/nihms584852.pdf) Preview |
|
PDF
Accepted Version
Available under License ["licenses_description_publisher" not defined].
Download (1MB)
| Preview
|
Abstract
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water transport across the plasma membranes of cells in response to osmotic gradients. Data from knockout mice support the involvement of AQPs in epithelial fluid secretion, cell migration, brain oedema and adipocyte metabolism, which suggests that modulation of AQP function or expression could have therapeutic potential in oedema, cancer, obesity, brain injury, glaucoma and several other conditions. Moreover, loss-of-function mutations in human AQPs cause congenital cataracts (AQP0) and nephrogenic diabetes insipidus (AQP2), and autoantibodies against AQP4 cause the autoimmune demyelinating disease neuromyelitis optica. Although some potential AQP modulators have been identified, challenges associated with the development of better modulators include the druggability of the target and the suitability of the assay methods used to identify modulators.
Item Type: |
Article
|
Additional Information: |
This is a post-peer-review, pre-copyedit version of an article published in Nature Reviews Drug Discovery. The final authenticated version is available online at: http://dx.doi.org/10.1038/nrd4226 |
Keywords: |
Animals, Aquaporins, Biological Transport, Cell Membrane, Drug Design, Humans, Mice, Mice, Knockout, Molecular Targeted Therapy, Osmosis, Water, Cell Membrane, Animals, Mice, Knockout, Humans, Mice, Water, Aquaporins, Osmosis, Biological Transport, Drug Design, Molecular Targeted Therapy, Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Pharmacology & Pharmacy, NEPHROGENIC DIABETES-INSIPIDUS, OSMOTIC WATER PERMEABILITY, URINARY CONCENTRATING ABILITY, INDUCED SALIVARY HYPOFUNCTION, NEUROMYELITIS-OPTICA IGG, HYDROGEN-PEROXIDE UPTAKE, HUMAN BRAIN-TUMORS, CELL-MIGRATION, TRANSGENIC MICE, XENOPUS-OOCYTES, 11 Medical And Health Sciences, 06 Biological Sciences, Pharmacology & Pharmacy |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Nat Rev Drug Discov |
ISSN: |
1474-1784 |
Language: |
eng |
Dates: |
Date | Event |
---|
April 2014 | Published | 14 March 2014 | Published Online |
|
Publisher License: |
Publisher's own licence |
Projects: |
Project ID | Funder | Funder ID |
---|
R01 EY013574 | NEI NIH HHS | UNSPECIFIED | R01 DK035124 | NIDDK NIH HHS | UNSPECIFIED | P30 DK072517 | NIDDK NIH HHS | UNSPECIFIED | R37 EB000415 | NIBIB NIH HHS | UNSPECIFIED | R01 DK101373 | NIDDK NIH HHS | UNSPECIFIED |
|
PubMed ID: |
24625825 |
Web of Science ID: |
WOS:000333906200022 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/107695 |
Publisher's version: |
https://doi.org/10.1038/nrd4226 |
Statistics
Item downloaded times since 14 May 2019.
Actions (login required)
![Edit Item](/style/images/action_view.png) |
Edit Item |