Hogan, LE; Jones, DC; Allen, RL
(2016)
Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure.
Sci Rep, 6.
p. 21780.
ISSN 2045-2322
https://doi.org/10.1038/srep21780
SGUL Authors: Allen, Rachel Louise
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Abstract
Antigen presenting cells (APC) are critical components of innate immunity and consequently shape the adaptive response. Leukocyte Ig Like Receptors (LILR) are innate immune receptors predominantly expressed on myeloid cells. LILR can influence the antigen presenting phenotype of monocytic cells to determine the nature of T cell responses in infections including Mycobaterium leprae. We therefore investigated the relevance of LILR in the context of Mycobacterium tuberculosis. Real-time PCR studies indicated that the transcriptional profile of the orphan receptor LILRB5 was significantly up-regulated following exposure to mycobacteria. Furthermore, LILRA1 and LILRB5 were able to trigger signalling through direct engagement of mycobacteria using tranfectant cells incorporating a reporter system. We describe for the first time the expression of this receptor on T cells, and highlight the potential relevance to mycobacterial recognition. Furthermore, we demonstrate that crosslinking of this receptor on T cells increases proliferation of cytotoxic, but not helper, T cells.
Item Type: | Article | |||||||||
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Additional Information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0 | |||||||||
Keywords: | Antigens, CD, BCG Vaccine, Cell Proliferation, Cells, Cultured, Dendritic Cells, Gene Expression, Humans, Immunity, Innate, Mycobacterium tuberculosis, Receptors, Immunologic, T-Lymphocytes, Vaccination | |||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | |||||||||
Journal or Publication Title: | Sci Rep | |||||||||
ISSN: | 2045-2322 | |||||||||
Language: | eng | |||||||||
Publisher License: | Creative Commons: Attribution 4.0 | |||||||||
Projects: |
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PubMed ID: | 26908331 | |||||||||
Web of Science ID: | WOS:000370862600001 | |||||||||
Go to PubMed abstract | ||||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/107634 | |||||||||
Publisher's version: | https://doi.org/10.1038/srep21780 |
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