Mula, M; von Oertzen, TJ; Cock, HR; Lozsadi, DA; Agrawal, N
(2016)
Clinical correlates of memory complaints during AED treatment.
Acta Neurologica Scandinavica, 134 (5).
pp. 368-373.
ISSN 1600-0404
https://doi.org/10.1111/ane.12553
SGUL Authors: Cock, Hannah Rutherford Von Oertzen, Tim Mula, Marco
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Abstract
OBJECTIVES: To investigate clinical correlates of memory complaints (MC) during anti-epileptic drug (AEDs) treatment in adults with epilepsy with special attention to the role of depression, using user-friendly standardized clinical instruments which can be adopted in any outpatient setting. MATERIALS & METHODS: Data from a consecutive sample of adult outpatients with epilepsy assessed with the Neurological Disorder Depression Inventory for Epilepsy (NDDIE), the Adverse Event Profile (AEP) and the Emotional Thermometer (ET) were analysed. RESULTS: From a total sample of 443 patients, 28.4% reported MC as 'always' a problem. These patients were less likely to be seizure free (18.3% vs 34.3%; P < 0.001), had a high number of previous AED trials (4 vs 3; P < 0.001) and high AEP total scores (49 vs 34.2; P < 0.001). There was no correlation with specific AED type or combination. Depression was the major determinant with a 2-fold increased risk (95%CI 1.15-3.86; P = 0.016). When depression was already known and under treatment, patients with MC were less likely to be in remission from depression despite antidepressant treatment (11.9% vs 1.6% P < 0.001). Among patients without depression, those reporting MC presented with significantly high scores for depression (3.3 vs 2; t = 3.07; P = 0.003), anxiety (4.5 vs 2.7; t = 4.43; P < 0.001), anger (3 vs 2; t = 2.623; P = 0.009) and distress (3.8 vs 2.2; t = 4.027; P < 0.001) than those without MC. CONCLUSIONS: Depression has to be appropriately treated and full remission from depression should represent the ultimate goal as subthreshold or residual mood and anxiety symptoms can contribute to MC.
Item Type: | Article | ||||||||
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Additional Information: | his is the peer reviewed version of the following article: Mula, M., von Oertzen, T. J., Cock, H. R., Lozsadi, D. A., Agrawal, N. Clinical correlates of memory complaints during AED treatment. Acta Neurologica Scandinavica , which has been published in final form at http://dx.doi.org/10.1111/ane.12553. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | ||||||||
Keywords: | adverse events, anti-epileptic drugs, antidepressant drugs, depression, epilepsy, memory, Neurology & Neurosurgery, 1103 Clinical Sciences | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Institute of Medical & Biomedical Education (IMBE) Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE ) |
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Journal or Publication Title: | Acta Neurologica Scandinavica | ||||||||
ISSN: | 1600-0404 | ||||||||
Language: | ENG | ||||||||
Dates: |
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Publisher License: | Publisher's own licence | ||||||||
PubMed ID: | 26756805 | ||||||||
Go to PubMed abstract | |||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/107612 | ||||||||
Publisher's version: | https://doi.org/10.1111/ane.12553 |
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